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A Mitocentric View of Alzheimer’s Disease

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease with an increasing morbidity, mortality, and economic cost. Plaques formed by amyloid beta peptide (Aβ) and neurofibrillary tangles formed by microtubule-associated protein tau are two main characters of AD. Though previous studies have focused on Aβ and tau and got some progressions on their toxicity mechanisms, no significantly effective treatments targeting the Aβ and tau have been found. However, it is worth noting that mounting evidences showed that mitochondrial dysfunction is an early event during the process of AD pathologic changes. What is more, these studies also showed an obvious association between mitochondrial dysfunction and Aβ/tau toxicity. Furthermore, both genetic and environmental factors may increase the oxidative stress and the mitochondria are also the sensitive target of ROS, which may form a vicious feedback between mitochondrial dysfunction and oxidative stress, eventually resulting in deficient energy, synaptic failure, and cell death. This article reviews the previous related studies from different aspects and concludes the critical roles of mitochondrial dysfunction in AD, suggesting a different route to AD therapy, which may guide the research and treatment direction.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (81000544, 81171209, 81571245, and 81501103), the Shandong Provincial Outstanding Medical Academic Professional Program, Qingdao Key Health Discipline Development Fund, Qingdao Outstanding Health Professional Development Fund, and Shan dong Provincial Collaborative Innovation Center for Neurodegenerative Disorders.

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  1. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China

    Hao Hu, Chen-Chen Tan, Lan Tan & Jin-Tai Yu

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  1. Hao Hu
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  2. Chen-Chen Tan
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  3. Lan Tan
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Correspondence to Lan Tan or Jin-Tai Yu.

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Hao Hu and Chen-Chen Tan are Equal contributors.

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Hu, H., Tan, CC., Tan, L. et al. A Mitocentric View of Alzheimer’s Disease. Mol Neurobiol 54, 6046–6060 (2017). https://doi.org/10.1007/s12035-016-0117-7

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