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Molecular Targets in Alzheimer’s Disease

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Abstract

Alzheimer’s disease (AD) is known as a devastating neurodegenerative disorder in aged subjects, which is related to multiple heterogeneous genetic factors. The two basic pathological aspects of AD are related to amyloid beta (Aβ) peptides and tau proteins. Some researchers have demonstrated plaques and tangles as apparently primary lesions. Also, experimental data propose that these two lesions are intimately related. In the present review, we highlight some molecular mechanisms linking tau and Aβ toxicities involving oxidative stress, aging, Aβ turnover, the contribution of thiol groups, and the role mitochondrial activities in the AD pathogenesis. Understanding the interplay of these mechanisms as parts of common pathophysiological pathways could reveal molecular targets to control or even treat AD.

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Authors and Affiliations

  1. Council for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i Rana, Norway

    Geir Bjørklund

  2. Faculty of Health and Social Science, Inland Norway University of Applied Sciences, Elverum, Norway

    Jan Aaseth

  3. Department of Research, Innlandet Hospital Trust, Brumunddal, Norway

    Jan Aaseth

  4. Agricultural Research, Education and Extension Organization (AREEO), Razi Vaccine and Serum Research Institute, Karaj, Iran

    Maryam Dadar

  5. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

    Salvatore Chirumbolo

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  1. Geir Bjørklund
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  2. Jan Aaseth
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  4. Salvatore Chirumbolo
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Bjørklund, G., Aaseth, J., Dadar, M. et al. Molecular Targets in Alzheimer’s Disease. Mol Neurobiol 56, 7032–7044 (2019). https://doi.org/10.1007/s12035-019-1563-9

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