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Photodynamic therapy in oral cancer: a review of clinical studies

  • Review Article
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Abstract

A significant mortality rate is associated with oral cancer, particularly in cases of late-stage diagnosis. Since the last decades, oral cancer survival rates have only gradually improved despite advances in treatment. This poor success rate is mainly due to the development of secondary tumors, local recurrence, and regional failure. Invasive treatments frequently have a negative impact on the aesthetic and functional outcomes of survivors. Novel approaches are thus needed to manage this deadly disease in light of these statistics. In photodynamic therapy (PDT), a light-sensitive medication called a photosensitizer is given first, followed by exposure to light of the proper wavelength that matches the absorbance band of the photosensitizer. The tissue oxygen-induced cytotoxic free radicals kill tumor cells directly, harm the microvascular structure, and cause inflammatory reactions at the targeted sites. In the case of early lesions, PDT can be used as a stand-alone therapy, and in the case of advanced lesions, it can be used as adjuvant therapy. The current review article discussed the uses of PDT in oral cancer therapy based on recent advances in this field.

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Acknowledgements

The authors thank their colleagues for their insightful comments.

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Authors and Affiliations

  1. Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Ali Mosaddad & Seyedeh Sara Aghili

  2. Dentistry Department, Bogomolets National Medical University, Kiev, Ukraine

    Reza Abdollahi Namanloo

  3. Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Elahe Tahmasebi & Mohsen Yazdanian

  4. Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mostafa Alam

  5. Department of Prosthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Kamyar Abbasi

  6. Department of Oral and Maxillofacial Surgery, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

    Farzad Nouri

  7. Department of Science and Research, Islimic Azade University, Tehran, Iran

    Hamid Tebyaniyan

  8. Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Poorya Maskani

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Mosaddad, S.A., Namanloo, R.A., Aghili, S.S. et al. Photodynamic therapy in oral cancer: a review of clinical studies. Med Oncol 40, 91 (2023). https://doi.org/10.1007/s12032-023-01949-3

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