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Photodynamic Diagnosis and Therapy for Oral Potentially Malignant Disorders and Cancers

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Development of Oral Cancer

Abstract

Regardless of the major advances in all standard diagnostic and therapeutic modalities, the 5-year survival of oral cancers is still 50% and has not improved over the past years. It is imperative to expand the horizon of the clinically utilized protocols for premalignant and malignant oral lesion control so as to include approved and minimally invasive ones such as photodynamic diagnosis (PDD) and photodynamic therapy (PDT). They both depend on the light activation of an otherwise chemically inert compound known as photosensitizer (PS). The energy gained from the light can be transferred into fluorescence or into production of deleterious reactive oxygen species (ROS). The first has a great value in tumor region visualization, while the second mediates PDT-associated antitumor activity. In this chapter, the light is shed on the concept behind PDD/PDT along with discussing their elements and cell death mechanisms. Importantly, a glimpse at the current status from the clinical point of view is presented accompanied with future directions.

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Notes

  1. 1.

    Retrieved from www.clinicaltrials.gov visited on 12.1.2017.

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  1. Pharmaceutical Biology Department, Photochemistry and Photodynamic Therapy Research Group, German University in Cairo (GUC), Cairo, Egypt

    Sara A. Abdel Gaber

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    Ala-Eddin Al Moustafa

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Abdel Gaber, S.A. (2017). Photodynamic Diagnosis and Therapy for Oral Potentially Malignant Disorders and Cancers. In: Al Moustafa, AE. (eds) Development of Oral Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-48054-1_10

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