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A Review of Photodynamic Therapy for Neoplasms of the Head and Neck

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Abstract

Photodynamic therapy (PDT) involves the use of a phototoxic drug which is activated by low powered laser light to destroy neoplastic cells. Multiple photosensitizers have been studied and tumors have been treated in a variety of head and neck sites over the last 30 years. PDT can effectively treat head and neck tumors, particularly those of the superficial spreading type, and the classic application of this technology has been in the patient with a wide field of dysplastic change and superficial carcinomatosis. Interstitial treatment has been used to treat more invasive cancer. Data is available from case series and institutional experiences, but very little randomized data is available. We review the mechanisms of action, historical development, available data, and current knowledge regarding PDT for the various head and neck subsites, and discuss possible future directions, with an emphasis on clinical application.

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Acknowledgements

This article was written by members and invitees of the International Head and Neck Scientific Group (www.IHNSG.com).

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No funding or sponsorship was received for this study or publication of this article.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Merrill Biel is Chief Medical Officer of Aspyrian Therapeutics. Dr Francisco J. Civantos, Barış Karakullukcu, Carl E. Silver, Alessandra Rinado, Nabil F. Saba, Robert P. Takes, Vincent Vander Poorten, and Alfio Ferlito have nothing to declare.

Compliance with Ethical Guidelines

This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA

    Francisco J. Civantos

  2. The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Barış Karakullukcu

  3. University of Minnesota, Minneapolis, MN, USA

    Merrill Biel

  4. Ear, Nose and Throat Specialty Care of Minnesota, Minneapolis, MN, USA

    Merrill Biel

  5. Department of Surgery, University of Arizona College of Medicine – Phoenix, Phoenix, AZ, USA

    Carl E. Silver

  6. University of Udine School of Medicine, Udine, Italy

    Alessandra Rinaldo

  7. Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA

    Nabil F. Saba

  8. Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands

    Robert P. Takes

  9. Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium

    Vincent Vander Poorten

  10. International Head and Neck Scientific Group, Padua, Italy

    Alfio Ferlito

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  1. Francisco J. Civantos
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A. Ferlito is the Coordinator of the International Head and Neck Scientific Group.

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Civantos, F.J., Karakullukcu, B., Biel, M. et al. A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. Adv Ther 35, 324–340 (2018). https://doi.org/10.1007/s12325-018-0659-3

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