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Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx

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Abstract

Therapeutic options for recurrent carcinoma of the upper aérodigestive tract (UADT) are limited. The prognosis of these tumours remains poor with significant rate of recurrence and a lower median survival time. Photodynamic therapy (PDT) is a relatively new therapeutic alternative which combines the use of a photosensitising agent and light to induce a cytotoxic effect on the tissues. This is a retrospective single-centre study carried out in patients with a recurrence of an oral cavity or oropharyngeal carcinoma or a second appearance of tumour in a previously irradiated area. There were no metastases in lymph nodes or other organs. Laser treatment was carried out 96 h after temoporfin (Foscan®) injection. In our series we had 14 cases with a complete response, 1 partial response. Overall survival at 1 year was 72 % and 36 % at 5 years. Disease-specific survival at 1 year was 82 % and 45 % at 5 years. Recurrence-free survival at 1 year was 52 % and 34 % at 5 years. Side effects mainly described are pain in the area of illumination, well controlled. PDT with Foscan® gives useful results in terms of survival and improvement in quality of life with few adverse events or severe complications. The fact that it has low toxicity and that treatment sessions can be repeated mean it should be considered in the therapeutic armamentarium for recurrent carcinoma of the UADT.

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References

  1. Carvalho AL, Magrin J, Kowalski LP (2003) Sites of recurrence in oral and oropharyngeal cancers according to the treatment approach. Oral Dis 9(3):112–118

    Article  PubMed  CAS  Google Scholar 

  2. Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M et al (2007) Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 357(17):1695–1704

    Google Scholar 

  3. Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P et al (1999) Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 91(24):2081–2086

    Google Scholar 

  4. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354(6):567–578

    Google Scholar 

  5. Kramer S, Marcial VA, Pajak TF, MacLean CJ, Davis LW (1986) Prognostic factors for loco/regional control and metastasis and the impact on survival. Int J Radiat Oncol Biol Phys 12:573–578

    Article  PubMed  CAS  Google Scholar 

  6. Kowalski LP, Carvalho AL (2000) Natural history of untreated head and neck cancer. Eur J Cancer 36(8):1032–1037

    Article  PubMed  CAS  Google Scholar 

  7. Schwartz GJ, Mehta RH, Wenig BL, Shaligram C, Portugal LG (2000) Salvage treatment for recurrent squamous cell carcinoma of the oral cavity. Head Neck 22:34–41

    Article  PubMed  CAS  Google Scholar 

  8. Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S et al (2008) Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359(11):1116–27

    Google Scholar 

  9. Da’Cruz AK, Robinson MH, Biel MA (2004) mTHPC-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients. Head Neck 26(3):232–240

    Article  Google Scholar 

  10. Tan IB, Dolivet G, Ceruse P, Vander Poorten V, Roest G, Rauschning W (2010) Temoporfin-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study. Head Neck 32(12):1597–1604

    Article  PubMed  Google Scholar 

  11. Henderson BW, Dougherty TJ (1992) How does photodynamic therapy work? Photochem Photobiol 55:145–157

    Article  PubMed  CAS  Google Scholar 

  12. Dilkes MG, Alusi G, Djaezeri BJ (1999) The treatment of head and neck cancer with photodynamic therapy: clinical experience. Rev Contemp Pharmacother 10:47–57

    CAS  Google Scholar 

  13. Fisher AM, Murphree AL, Gomer CJ (1995) Clinical and preclinical photodynamic therapy. Lasers Surg Med 17:2–31

    Article  PubMed  CAS  Google Scholar 

  14. Hopper C (2000) Photodynamic therapy: a clinical reality in the treatment of cancer. Lancet Oncol (1):212–9

  15. Hornung R, Walt H, Crompton NE et al (1998) m-THPC-mediated photodynamic therapy (PDT) does not induce resistance to chemotherapy, radiotherapy or PDT on human breast cancer cells in vitro. Photochem Photobiol 68(4):569–74

    Google Scholar 

  16. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L et al (2000) New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92:205–16

    Google Scholar 

  17. Carvalho AL, Salvajoli JV, Kowalski LP (2000) A comparison of radiotherapy or radiochemotherapy with symptomatic treatment alone in patients with advanced head and neck carcinomas. Eur Arch Otorhinolaryngol 257:164–167

    Article  PubMed  CAS  Google Scholar 

  18. Bensadoun RJ, Magne N, Marcy PY, Demard F (2001) Chemotherapy- and radiotherapy-induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment. Eur Arch Otorhinolaryngol 258:481–487

    Article  PubMed  CAS  Google Scholar 

  19. Forastiere A, Koch W, Trotti A, Sidransky D (2001) Head and neck cancer. N Engl J Med 345:1890–1900

    Article  PubMed  CAS  Google Scholar 

  20. Forastiere AA, Metch B, Schuller DE et al (1992) Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study. J Clin Oncol 10:1245–1251

    Google Scholar 

  21. Wheeler RH (1990) Chemotherapy of patients with recurrent head and neck cancer. In: Jacobs C (ed) Carcinomas of the head and neck: evaluation and management. Kluwer, Boston, pp 171–193

  22. Lorenz KH, Maier H (2009) Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan®) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients. Eur Arch Otorhinolaryngol 266:1937–1944

    Article  PubMed  Google Scholar 

  23. Esteller E, Vega MC, López M, Quer M, León X (2011) Salvage surgery after locoregional failure in head and neck carcinoma patients treated with chemoradiotherapy. Eur Arch Otorhinolaryngol 268(2):295–301

    Article  PubMed  CAS  Google Scholar 

  24. Hopper C, Niziolb C, Sidhub M (2004) The cost-eVectiveness of Foscan mediated photodynamic therapy (Foscan-PDT) compared with extensive palliative surgery and palliative chemotherapy for patients with advanced head and neck cancer in the UK. Oral Oncol 40:372–382

    Article  PubMed  CAS  Google Scholar 

  25. Kübler A et al (2005) Eine Kosten-EVektivitätsanalyse der photodynamischen Therapie mit Foscan im Vergleich zur palliativen Chemotherapie bei Patienten mit fortgeschrittenen Kopf-Halstumoren in Deutschland. Laryngorhinootologie 84:1–8

    Google Scholar 

  26. Bonnett R (1999) Photodynamic therapy in historical perspective. Rev Contemp Pharmacother 10:1–17

    CAS  Google Scholar 

  27. Copper MP, Tan IB, Oppelaar H, Ruevekamp MC, Stewart FA (2003) Meta-tetra(hydroxyphenyl)chlorin photodynamic therapy in early-stage squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 129:709–711

    Article  PubMed  Google Scholar 

  28. Grant WE, Hopper C, Speight PM, MacRobert AJ, Bown SG (1993) Photodynamic therapy of malignant and premalignant lesions in patients with Weld cancerization of the oral cavity. J Laryngol Otol 107:1140–1145

    Article  PubMed  CAS  Google Scholar 

  29. Hopper C, Kübler A, Lewis H, Tan B, Putnam G (2004) mTHPCmediated photodynamic therapy for early oral squamous cell carcinoma. Int J Cancer 111:138–146

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. ENT Department, Hospices Civils de Lyon, Centre hospitalier Lyon Sud, Pierre-Bénite Cedex, France

    M. Durbec, A. Cosmidis, C. Fuchsmann & P. Céruse

  2. ENT Department, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon Cedex, France

    A. Ramade & P. Céruse

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  1. M. Durbec
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  2. A. Cosmidis
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  3. C. Fuchsmann
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  4. A. Ramade
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  5. P. Céruse
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Correspondence to M. Durbec.

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Durbec, M., Cosmidis, A., Fuchsmann, C. et al. Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx. Eur Arch Otorhinolaryngol 270, 1433–1439 (2013). https://doi.org/10.1007/s00405-012-2083-7

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  • DOI: https://doi.org/10.1007/s00405-012-2083-7

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