Abstract
Based on our theory, we have discovered main triplets of amino acid residues in cell-adhesion receptors of marine sponges, which appear also as homologies in several receptor heteromers of human brain. The obtained results strengthen our hypothesis that these triplets may “guide-and-clasp” receptor–receptor interactions.
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References
Agnati LF, Franzen O, Ferre S, Leo G, Franco R, Fuxe K (2003) Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia. J Neural Transm Suppl 65:1–28
Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783–801
Borroto-Escuela DO, Narvaez M, Marcellino D, Parrado C, Narvaez JA, Tarakanov AO, Agnati LF, Diaz-Cabiale Z, Fuxe K (2010) Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization. Bioch Biophys Res Commun 393:767–772
Borroto-Escuela DO, Tarakanov AO, Guidolin D, Ciruela F, Agnati LF, Fuxe K (2011) Moonlight characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration. IUBMB Life 63:463–472
Borroto-Escuela DO, Romero-Fernandez W, Mudo G, Perez-Alea M, Ciruela F, Tarakanov AO, Narvaez M, Di Liberto V, Agnati LF, Belluardo N, Fuxe K (2012a) FGFR1-5-HT1A heteroreceptor complexes and their enhacement of hippocampal plasticity. Biol Psych 71:84–91
Borroto-Escuela DO, Romero-Fernandez W, Perez-Alea M, Narvaez M, Tarakanov AO, Mudo G, Agnati LF, Ciruela F, Belluardo N, Fuxe K (2012b) The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. J Neurosci 32:6295–6303
Buljan M, Bateman A (2009) The evolution of protein domain families. Biochem Soc Trans 37:751–755
Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A (2006) Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF2 in human cells. Blood 107:1896–1902
Fuxe K, Canals M, Torvinen M et al (2007) Intramembrane receptor–receptor interactions: a novel principle in molecular medicine. J Neural Transm 114:49–75
Fuxe K, Borroto-Escuela DO, Marcellino D, Romero-Fernandez W, Frankowska M, Guidolin D, Filip M, Ferraro L, Woods AS, Tarakanov A, Ciruela F, Agnati LF, Tanganelli S (2012) GPCR heteromers and their allosteric receptor–receptor interactions. Curr Med Chem 19:356–363
Gamulin V, Rinkevich B, Schäcke H, Kruse M, Müller IM, Müller WE (1994) Cell adhesion receptors and nuclear receptors are highly conserved from the lowest metazoa (marine sponges) to vertebrates. Biol Chem Hoppe Seyler 375:583–588
Gonzalez-Maeso J et al (2008) Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452:93–97
Hague C, Lee SE, Chen Z, Prinster SC, Hall RA, Minneman KP (2006) Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity. Mol Pharmacol 69:45–55
Hirono M, Yoshioka T, Konishi S (2001) GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses. Nat Neurosci 4:1207–1216
Hynes RQ (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110:673–687
Jin MS, Kim SE, Heo JY et al (2007) Crystal structure of the TL1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071–1082
Kobe B, Kajava AV (2001) The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 11:725–732
Kumar CC (1998) Signaling by integrin receptors. Oncogene 17:1365–1373
Landschulz WH, Johnson PF, McKnight SL (1988) The leucine zipper: a hypothetical structure common to a new class of DNA-binding proteins. Science 240:1759–1764
Muller WEG (1997) Origin of metazoan adhesion molecules and adhesion receptors as deduced from cDNA analyses in the marine sponge Geodia cydonium: a review. Cell Tissue Res 289:383–395
Pancer Z, Kruse M, Muller I, Muller WEG (1997) On the origin of metazoan adhesion receptors: cloning of integrin α subunit from the sponge Geodia cydonium. Mol Biol Evol 14:391–398
Romero-Fernandez W, Borroto-Escuela DO, Tarakanov AO et al (2011) Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family. Biochem Biophys Res Commun 409:764–768
Tarakanov AO, Fuxe KG (2010) Triplet puzzle: homologies of receptor heteromers. J Mol Neurosci 41:294–303
Tarakanov AO, Fuxe KG (2011) The triplet puzzle of homologies in receptor heteromers exists also in other types of protein–protein interactions. J Mol Neurosci 44:173–177
Tarakanov AO, Fuxe KG, Agnati LF, Goncharova LB (2009) Possible role of receptor heteromers in multiple sclerosis. J Neural Transm 116:989–994
Tarakanov AO, Fuxe KG, Borroto-Escuela DO (2012) On the origin of the triplet puzzle of homologies in receptor heteromers: Immunoglobulin triplets in different types of receptors. J Mol Neurosci 46:616–621
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Tarakanov, A.O., Fuxe, K.G. & Borroto-Escuela, D.O. Integrin Triplets of Marine Sponges in Human Brain Receptor Heteromers. J Mol Neurosci 48, 154–160 (2012). https://doi.org/10.1007/s12031-012-9793-6
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DOI: https://doi.org/10.1007/s12031-012-9793-6