Abstract
Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may “guide-and-clasp” receptor–receptor interactions playing a role, e.g., in neuroinflammation disorders.
Similar content being viewed by others
References
Borroto-Escuela DO, Tarakanov AO, Guidolin D, Ciruela F, Agnati LF, Fuxe K (2011a) Moonlight characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration. IUBMB Life 63:463–472
Borroto-Escuela DO, Romero-Fernandez W, Mudo G et al. (2011b) FGFR1-5-HT1A heteroreceptor complexes and their enhacement of hippocampal plasticity. Biol Psych (under revision)
Buljan M, Bateman A (2009) The evolution of protein domain families. Biochem Soc Trans 37:751–755
Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A (2006) Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF2 in human cells. Blood 107:1896–1902
Fuxe K, Canals M, Torvinen M et al (2007) Intramembrane receptor-receptor interactions: a novel principle in molecular medicine. J Neural Transm 114:49–75
Gamulin V, Rinkevich B, Schäcke H, Kruse M, Müller IM, Müller WE (1994) Cell adhesion receptors and nuclear receptors are highly conserved from the lowest metazoa (marine sponges) to vertebrates. Biol Chem Hoppe Seyler 375:583–588
Guyon A, Nahon JL (2007) Multiple actions of the chemokine stromal cell-derived factor-1a on neuronal activity. J Mol Endocrinol 38:365–376
Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Wilson TA (1996) Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci USA 96:497–501
Hirono M, Yoshioka T, Konishi S (2001) GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses. Nat Neurosci 4:1207–1216
Mizuno T, Zhang G, Takeuchi H et al (2008) Interferon-γ directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-γ receptor and AMPA GluR1 receptor. FASEB J 22:1797–1806
Rocheville M, Lange DC, Kumar U, Sasi R, Patel SC, Patel YC (2000) Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem 275:7862–7869
Romero-Fernandez W, Borroto-Escuela DO, Tarakanov AO et al (2011) Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family. Biochem Biophys Res Commun 409:764–768
Suzuki S, Chuang LF, Yau P, Doi RH, Chuang RY (2002) Interactions of opioid and chemokine receptors: oligomerization of mu, kappa and delta with CCR5 on immune cells. Exp Cell Res 280:192–200
Tarakanov AO, Fuxe KG (2010) Triplet puzzle: homologies of receptor heteromers. J Mol Neurosci 41:294–303
Tarakanov AO, Fuxe KG (2011) The triplet puzzle of homologies in receptor heteromers exists also in other types of protein-protein interactions. J Mol Neurosci 44:173–177
Tarakanov AO, Fuxe KG, Agnati LF, Goncharova LB (2009) Possible role of receptor heteromers in multiple sclerosis. J Neural Transm 116:989–994
Author information
Authors and Affiliations
Corresponding author
Electronic Supplementary Material
Below is the link to the electronic supplementary material.
ESM 1
(DOC 280 kb)
Rights and permissions
About this article
Cite this article
Tarakanov, A.O., Fuxe, K.G. & Borroto-Escuela, D.O. On the Origin of the Triplet Puzzle of Homologies in Receptor Heteromers: Immunoglobulin Triplets in Different Types of Receptors. J Mol Neurosci 46, 616–621 (2012). https://doi.org/10.1007/s12031-011-9649-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12031-011-9649-5