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Evolution of Cell Adhesion to Extracellular Matrix

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Evolution of Extracellular Matrix

Part of the book series: Biology of Extracellular Matrix ((BEM))

Abstract

The extracellular matrix and cell adhesion receptors, especially the integrins, have played a major role in the emergence of multicellular animals. The members of the integrin family can be found in all present-day metazoans, and they actually predate the origin of the animal kingdom. Chordate integrins show structural and functional diversity, and they gather around themselves a large number of adaptor and signaling proteins, an adhesome. This chapter reviews the early evolution of integrin-type protein domains, the origin of integrin-dependent adhesion mechanisms, and the later developments in chordate-specific integrins.

Please note the Erratum to this chapter at the end of the book

An erratum to this chapter is available at http://dx.doi.org/978-3-642-36002-2_10

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-642-36002-2_10

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Authors and Affiliations

  1. Department of Biosciences, Åbo Akademi University, Turku, Finland

    Mark S. Johnson, Tomi Airenne & Bhanupratap Singh Chouhan

  2. Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

    Jarmo Käpylä & Jyrki Heino

  3. Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

    Konstantin Denessiouk

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  1. Hospital for Sick Children, Toronto, Ontario, Canada

    Fred W. Keeley

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Johnson, M.S., Käpylä, J., Denessiouk, K., Airenne, T., Chouhan, B.S., Heino, J. (2013). Evolution of Cell Adhesion to Extracellular Matrix. In: Keeley, F., Mecham, R. (eds) Evolution of Extracellular Matrix. Biology of Extracellular Matrix. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36002-2_9

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