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Possible role of receptor heteromers in multiple sclerosis

  • Basic Neurosciences, Genetics and Immunology - Original Article
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Abstract

Recent results suggest that cytokine and glutamate receptors can interact directly and form receptor heteromers. Due to such heteromers, cytokines can act not only as classical neuromediators but also directly enhance glutamate gated ion channel activity via allosteric mechanisms. Our opinion is that such heteromers may lead to enhanced glutamate neurotoxicity in pathogenic processes of multiple sclerosis. Thus, agents targeting evolutionary conserved leucine-rich motifs responsible for such dimerization of receptors may represent a useful strategy to inhibit excitotoxicity in multiple sclerosis.

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Authors and Affiliations

  1. St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, St. Petersburg, Russia

    A. O. Tarakanov

  2. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden

    K. G. Fuxe

  3. Department of Biomedical Sciences, University of Modena, Modena, Italy

    L. F. Agnati

  4. City Diagnostic Center (Virology), St. Petersburg, Russia

    L. B. Goncharova

Authors
  1. A. O. Tarakanov
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  2. K. G. Fuxe
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  3. L. F. Agnati
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  4. L. B. Goncharova
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Corresponding author

Correspondence to A. O. Tarakanov.

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Tarakanov, A.O., Fuxe, K.G., Agnati, L.F. et al. Possible role of receptor heteromers in multiple sclerosis. J Neural Transm 116, 989–994 (2009). https://doi.org/10.1007/s00702-009-0197-x

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  • DOI: https://doi.org/10.1007/s00702-009-0197-x

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