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Hierarchical bioactive materials for tissue reconstruction: Integrated design and manufacturing challenges

  • Biomaterials for Regenerative Medicine
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Abstract

Although the paradigm shift from synthetic implants and tissue grafts to regenerative-medicine-based tissue reconstruction has been promised for well over a decade, the reality has yet to emerge. A significant reason for this delay is that regenerative medicine reconstruction solutions involve complex systems in which bioresorbable materials are integrated with surface modifications delivering cells and growth factors. These systems must not only fill complex shapes and provide temporary mechanical function; they must deliver biologic factors that stimulate tissue growth in a controlled, safe, yet rapid manner. Finally, the materials should degrade on a timeline matched to the time it takes to grow tissues. As such, these material device systems are multifunctional and require design techniques that can address multifunctionality, coupled with multiple material manufacturing processes that can be integrated to achieve the design. In this paper, we review these design and manufacturing processes as well as the challenges to integrate these multiple design and manufacturing processes to engineer bioactive material devices.

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  1. Scaffold Tissue Engineering Group, Departments of Biomedical Engineering, Mechanical Engineering and Surgery, The University of Michigan, Ann Arbor, USA

    Scott J. Hollister

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Hollister, S.J. Hierarchical bioactive materials for tissue reconstruction: Integrated design and manufacturing challenges. JOM 63, 56–65 (2011). https://doi.org/10.1007/s11837-011-0060-z

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