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Selective laser sintering of porous tissue engineering scaffolds from poly(l-lactide)/carbonated hydroxyapatite nanocomposite microspheres

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Abstract

This study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(l-lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had a size range of 5–30 μm, suitable for the SLS process. Microstructural analyses revealed that the CHAp nanospheres were embedded throughout the PLLA microsphere, forming a nanocomposite structure. A custom-made miniature sintering platform was installed in a commercial Sinterstation® 2000 SLS machine. This platform allowed the use of small quantities of biomaterials for TE scaffold production. The effects of laser power; scan spacing and part bed temperature were investigated and optimized. Finally, porous scaffolds were successfully fabricated from the PLLA microspheres and PLLA/CHAp nanocomposite microspheres. In particular, the PLLA/CHAp nanocomposite microspheres appeared to be promising for porous bone TE scaffold production using the SLS technique.

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Acknowledgement

This work was supported by a CERG research grant (HKU 7118/05E) from the Hong Kong Research Grants Council.

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Authors and Affiliations

  1. Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China

    Wen You Zhou, Siu Hang Lee, Min Wang & Wai Lam Cheung

  2. Department of Orthopaedics and Traumatology, The University of Hong Kong, Sassoon Road, Hong Kong, China

    Wing Yuk Ip

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  1. Wen You Zhou
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  2. Siu Hang Lee
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  3. Min Wang
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  4. Wai Lam Cheung
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  5. Wing Yuk Ip
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Correspondence to Wai Lam Cheung.

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Zhou, W.Y., Lee, S.H., Wang, M. et al. Selective laser sintering of porous tissue engineering scaffolds from poly(l-lactide)/carbonated hydroxyapatite nanocomposite microspheres. J Mater Sci: Mater Med 19, 2535–2540 (2008). https://doi.org/10.1007/s10856-007-3089-3

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  • DOI: https://doi.org/10.1007/s10856-007-3089-3

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