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Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells

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Abstract

In this study, MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of a tetraorthosilicate precursor on a template self-assembled by cetyltrimethylammonium bromide in alkaline. The small-angle x-ray diffraction patterns of MCM-41 indicate that silica nanoparticles possess hexagonal structures with a high degree of structural ordering. Transmission electron microscopy images show that the size of the MCM-41 particles is around 100-120 nm, and the pore sizes range from 2 nm to 4 nm. In addition, the specific surface area of MCM-41 obtained by Brunauer–Emmett–Teller analysis is as high as 987 m2.g−1 and the pore size extracted from nitrogen physical adsorption isotherms is in accordance with the TEM result. Thermogravimetric analysis, Fourier-transform infrared spectroscopy, Zeta potential measurements and photoluminescence measurements show that 3-aminopropyltriethoxysilane (APTES) and doxorubicin were grafted and loaded successfully onto MCM-41 nanoparticles. An assay on fibroblasts, A549 and doxorubicin-resistant A549/DOX cells indicates that the prepared MCM41 grafting APTES nanoparticles are safe to normal cells and toxic to cancer cells in vitro.

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Acknowledgments

This research is funded by the Vietnam National University, Ho Chi Minh City (VNU-HCM) under Grant Number C2018-18-26.

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Author notes

  1. Dau Tran Anh Nguyet and Le Van Manh Hung have contributed equally to this work.

Authors and Affiliations

  1. Faculty of Materials Science and Technology, University of Science, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam

    Tran Anh Nguyet Dau, Van Hieu Le, Thai Ngoc Uyen Nguyen, Thi Kieu Hanh Ta & Thi Thanh Van Tran

  2. Vietnam National University, Ho Chi Minh City, Viet Nam

    Tran Anh Nguyet Dau, Van Hieu Le, Thai Ngoc Uyen Nguyen, Thi Kieu Hanh Ta & Thi Thanh Van Tran

  3. School of Biomaterials Science and Technology, College of Applied Life Sciences, Jeju National University, Jeju, 63243, Republic of Korea

    Van Manh Hung Le & Somi Kim Cho

  4. Department of Chemistry, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 461-701, Republic of Korea

    Thi Kim Hong Pham

  5. Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju, 63243, Republic of Korea

    Somi Kim Cho

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  1. Tran Anh Nguyet Dau
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Dau, T.A.N., Le, V.M.H., Pham, T.K.H. et al. Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells. J. Electron. Mater. 50, 2932–2939 (2021). https://doi.org/10.1007/s11664-021-08813-y

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