Skip to main content
SpringerLink
Log in

Emerging Theranostic Silver Nanomaterials to Combat Lung Cancer: A Systematic Review

  • ReviewPaper
  • Published:
Journal of Cluster Science Aims and scope Submit manuscript

Abstract

Lung cancer remains the leading cause of one-quarter of all cancer deaths and it’s a major public health problem worldwide. Nanotechnology offers a novel strategy to combat lung cancer. Recently, biologically synthesized silver nanoparticles (AgNPs) has attracted significant attention for their anticancer effects against lung cancer. Thereby, the current study was aimed to systematically review the efficacy of these nanoparticles (NPs) against lung cancer through in vitro models. The articles were collected through online databases comprising Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and Embase. Among all studies, the plant-mediated synthesis of AgNPs was the general approach. Besides, A549 lung cancer cell line was the predominant cell line that was applied for cytotoxicity assessment among all studies. Most of the AgNPs were synthesized with spherical morphology less than 100 nm. Interestingly, in almost all of the studies, AgNPs exhibited the half maximal inhibitory concentration (IC50) against lung cancer cells. We provided preliminary evidence indicating the significant anticancer activity of biogenic AgNPs. We also discussed the proposed anticancer mechanisms. However, further studies are required to evaluate the anticancer efficacy of biogenic AgNPs through in vivo models.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. R. L. Siegel, K. D. Miller, and A. Jemal (2019). CA Cancer J Clin.69, 7.

    PubMed  Google Scholar 

  2. M. L. Janssen-Heijnen and J. W. Coebergh (2003). Lung Cancer.41, 245.

    PubMed  Google Scholar 

  3. R. Pakzad, A. Mohammadian-Hafshejani, M. Ghoncheh, I. Pakzad, and H. Salehiniya (2015). Transl Lung Cancer Res.4, 763.

    PubMed  PubMed Central  Google Scholar 

  4. V. Winkler, J. J. Ott, M. Cowan, and H. Becher (2013). Prev Med.57, 634.

    PubMed  Google Scholar 

  5. C. Ferreiro, I. E. Alcamo, and D. Heymann Lung cancer (Infobase Publishing, New York, US, 2007).

    Google Scholar 

  6. H. Weaver and A. S. Coonar (2017). Surgery.35, 247.

    Google Scholar 

  7. F. Mottaghitalab, M. Farokhi, Y. Fatahi, F. Atyabi, and R. Dinarvand (2019). J Control Release.295, 250.

    CAS  PubMed  Google Scholar 

  8. M. M. Or Rashid, M. S. Islam, M. A. Haque, M. A. Rahman, M. T. Hossain, and M. A. Hamid (2016). Iran J Pharm Res.15, 591.

    PubMed  PubMed Central  Google Scholar 

  9. Q. Abbas, M. Saleem, A. R. Phull, M. Rafiq, M. Hassan, K.-H. Lee, and S.-Y. Seo (2017). Iran J Pharm Res.16, 760.

    CAS  Google Scholar 

  10. R. Dobrucka (2017). Iran J Pharm Res.16, 753.

    CAS  Google Scholar 

  11. N. Karimi, A. Chardoli, and A. Fattahi (2017). Iran J Pharm Res.16, 1167.

    PubMed  PubMed Central  Google Scholar 

  12. M. Maham and R. Karami-Osboo (2017). Iran J Pharm Res.16, 462.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. T. Ramezani, M. Nabiuni, J. Baharara, K. Parivar, and F. Namvar (2019). Iran J Pharm Res.18, 222.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Z. R. Amin, Z. Khashyarmanesh, B. S. Bazzaz, and Z. S. Noghabi (2019). Iran J Pharm Res.18, 210.

    CAS  Google Scholar 

  15. S. Salari, S. Bahabadi, A. Samzadeh-Kermani, and F. Yousefzaei (2019). Iran J Pharm Res.18, 430.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. B. Miri, N. Motakef-Kazemi, S. A. Shojaosadati, and A. Morsali (2018). Iran J Pharm Res.17, 1164.

    PubMed  PubMed Central  Google Scholar 

  17. J. Park, J. Park, E. J. Ju, S. S. Park, J. Choi, J. H. Lee, K. J. Lee, S. H. Shin, E. J. Ko, I. Park, C. Kim, J. J. Hwang, J. S. Lee, S. Y. Song, S. Y. Jeong, and E. K. Choi (2015). J Control Release.207, 77.

    CAS  PubMed  Google Scholar 

  18. Y. H. Chen, C. Y. Tsai, P. Y. Huang, M. Y. Chang, P. C. Cheng, C. H. Chou, D. H. Chen, C. R. Wang, A. L. Shiau, and C. L. Wu (2007). Mol Pharm.4, 713.

    CAS  PubMed  Google Scholar 

  19. H. Barabadi, K. D. Kamali, F. J. Shoushtari, B. Tajani, M. A. Mahjoub, A. Alizadeh, and M. Saravanan (2019). J Clust Sci.. https://doi.org/10.1007/s10876-019-01588-7.

    Article  Google Scholar 

  20. H. Barabadi, M. A. Mahjoub, B. Tajani, A. Ahmadi, Y. Junejo, and M. Saravanan (2019). J Clust Sci.30, 259.

    CAS  Google Scholar 

  21. M. Valodkar, R. N. Jadeja, M. C. Thounaojam, R. V. Devkar, and S. Thakore (2011). Mater Sci Eng C Mater Biol Appl.31, 1723.

    CAS  Google Scholar 

  22. R. Sankar, A. Karthik, A. Prabu, S. Karthik, K. S. Shivashangari, and V. Ravikumar (2013). Colloids Surf B Biointerfaces.108, 80.

    CAS  PubMed  Google Scholar 

  23. N. Kanipandian, S. Kannan, R. Ramesh, P. Subramanian, and R. Thirumurugan (2014). Mater Res Bull.49, 494.

    CAS  Google Scholar 

  24. D. Qu, W. Sun, Y. Chen, J. Zhou, and C. Liu (2014). Int J Nanomedicine.9, 1871.

    PubMed  PubMed Central  Google Scholar 

  25. R. Subbaiya and M. Selvam (2014). Curr Nanosci.10, 243.

    CAS  Google Scholar 

  26. S. Thakore, P. S. Rathore, R. N. Jadeja, M. Thounaojam, and R. V. Devkar (2014). Mater Sci Eng C Mater Biol Appl.44, 209.

    CAS  PubMed  Google Scholar 

  27. B. Venkatesan, V. Subramanian, A. Tumala, and E. Vellaichamy (2014). Asian Pac J Trop Med.7, S294.

    CAS  Google Scholar 

  28. K. Khanra, S. Panja, I. Choudhuri, A. Chakraborty, and N. Bhattacharyya (2015). Nano Biomed Eng.7, 128.

    CAS  Google Scholar 

  29. D. Mukundan, R. Mohankumar, and R. Vasanthakumari (2015). Mater Today Proc.2, 4309.

    Google Scholar 

  30. P. S. Kumar, C. Balachandran, V. Duraipandiyan, D. Ramasamy, S. Ignacimuthu, and N. A. Al-Dhabi (2015). Appl Nanosci.5, 169.

    Google Scholar 

  31. H. M. Abd-Elnaby, G. M. Abo-Elala, U. M. Abdel-Raouf, and M. M. Hamed (2016). Egypt J Aquat Res.42, 301.

    Google Scholar 

  32. V. Castro-Aceituno, S. Ahn, S. Y. Simu, P. Singh, R. Mathiyalagan, H. A. Lee, and D. C. Yang (2016). Biomed Pharmacother.84, 158.

    CAS  PubMed  Google Scholar 

  33. J. Du, H. Singh, and T.-H. Yi (2016). Bioprocess Biosyst Eng.39, 1923.

    CAS  PubMed  Google Scholar 

  34. Y. He, Z. Y. Du, S. J. Ma, Y. Liu, D. L. Li, H. R. Huang, S. Jiang, S. P. Cheng, W. J. Wu, K. Zhang, and X. Zheng (2016). Int J Nanomedicine. 11.

  35. G. Kuppurangan, B. Karuppasamy, K. Nagarajan, R. K. Sekar, N. Viswaprakash, and T. Ramasamy (2016). Appl Nanosci.6, 973.

    CAS  Google Scholar 

  36. V. Maharani, A. Sundaramanickam, and T. Balasubramanian (2016). Enzyme Microb. Technol.95, 146.

    CAS  PubMed  Google Scholar 

  37. S. Rajeshkumar, C. Malarkodi, M. Vanaja, and G. Annadurai (2016). J. Mol. Struct.1116, 165.

    CAS  Google Scholar 

  38. C. Wang, R. Mathiyalagan, Y. J. Kim, V. Castro-Aceituno, P. Singh, S. Ahn, D. Wang, and D. C. Yang (2016). Int J Nanomedicine.11, 3691.

    CAS  PubMed  PubMed Central  Google Scholar 

  39. M. S. Bethu and J. Rao (2017). Asian J Pharm Clin Res.10, 65.

    Google Scholar 

  40. V. Castro-Aceituno, R. Abbai, S. S. Moon, S. Ahn, R. Mathiyalagan, Y. J. Kim, Y. J. Kim, and D. C. Yang (2017). Biomed Pharmacother.93, 995.

    CAS  PubMed  Google Scholar 

  41. L. Ma, W. Su, J. X. Liu, X. X. Zeng, Z. Huang, W. Li, Z. C. Liu, and J. X. Tang (2017). Mater Sci Eng C Mater Biol Appl.77, 963.

    CAS  PubMed  Google Scholar 

  42. J. R. Nakkala, R. Mata, and S. R. Sadras (2017). J. Colloid Interface Sci.499, 33.

    CAS  PubMed  Google Scholar 

  43. N. G. Shimpi and M. Jha (2017). Int J Pharm Sci Res.8, 5100.

    CAS  Google Scholar 

  44. H. Singh, J. Du, and T.-H. Yi (2017). Artif Cells Nanomed Biotechnol.45, 1310.

    CAS  PubMed  Google Scholar 

  45. N. Vasanth, G. Melchias, and P. Kumaravel (2017). Asian J Pharm Clin Res.10, 93.

    CAS  Google Scholar 

  46. K. Venugopal, H. Ahmad, E. Manikandan, K. T. Arul, K. Kavitha, M. K. Moodley, K. Rajagopal, R. Balabhaskar, and M. Bhaskar (2017). J Photochem Photobiol B.173, 99.

    CAS  PubMed  Google Scholar 

  47. K. Venugopal, H. A. Rather, K. Rajagopal, M. P. Shanthi, K. Sheriff, M. Illiyas, R. A. Rather, E. Manikandan, S. Uvarajan, M. Bhaskar, and M. Maaza (2017). J Photochem Photobiol B.167, 282.

    CAS  PubMed  Google Scholar 

  48. D. A. Selvan, D. Mahendiran, R. S. Kumar, and A. K. Rahiman (2018). J Photochem Photobiol B.180, 243.

    Google Scholar 

  49. M. S. Bethu, V. R. Netala, L. Domdi, V. Tartte, and V. R. Janapala (2018). Artif Cells Nanomed Biotechnol.46, S104.

    Google Scholar 

  50. M. Dadashpour, A. Firouzi-Amandi, M. Pourhassan-Moghaddam, M. J. Maleki, N. Soozangar, F. Jeddi, M. Nouri, N. Zarghami, and Y. Pilehvar-Soltanahmadi (2018). Mater Sci Eng C Mater Biol Appl.92, 902.

    CAS  PubMed  Google Scholar 

  51. C. G. Kim, V. Castro-Aceituno, R. Abbai, H. A. Lee, S. Y. Simu, Y. Han, J. Hurh, Y. J. Kim, and D. C. Yang (2018). Biomed Pharmacother.99, 128.

    CAS  PubMed  Google Scholar 

  52. G. Lakshmanan, A. Sathiyaseelan, P. T. Kalaichelvan, and K. Murugesan (2018). Karbala Int. J. Mod. Sci.4, 61.

    Google Scholar 

  53. L. Ma, J. Liu, W. Su, X. Zeng, X. Liu, W. Li, J. Deng, and J. Tang (2018). J Nanosci Nanotechnol.18, 8133.

    CAS  PubMed  Google Scholar 

  54. Y. Periyasamy, B. Baskaran, V. Senniappan, and S. Chidambaram (2018). Mater Res Express. 5.

  55. M. Suganya, S. Kavitha, B. Gnanamangai, and P. Ponmurugan (2018). IET Nanobiotechnol.12, 318.

    Google Scholar 

  56. R. Vijayan, S. Joseph, and B. Mathew (2018). Artif Cells Nanomed Biotechnol.46, 861.

    CAS  PubMed  Google Scholar 

  57. H. I. Abo-Elmagd and M. M. Housseiny (2019). J Clust Sci.. https://doi.org/10.1007/s10876-019-01546-3.

    Article  Google Scholar 

  58. T. Akther, V. Mathipi, N. S. Kumar, M. Davoodbasha, and H. Srinivasan (2019). Environ Sci Pollut Res Int.26, 13649.

    CAS  PubMed  Google Scholar 

  59. M. Anandan, G. Poorani, P. Boomi, K. Varunkumar, K. Anand, A. A. Chuturgoon, M. Saravanan, and H. G. Prabu (2019). Process Biochem.80, 80.

    CAS  Google Scholar 

  60. A. Ayromlou, S. Masoudi, and A. Mirzaie (2019). J Clust Sci.. https://doi.org/10.1007/s10876-019-01563-2.

    Article  Google Scholar 

  61. D. Latha, P. Prabu, G. Gnanamoorthy, S. Sampurnam, R. Manikandan, C. Arulvasu, and V. Narayanan (2019). Mater Res Express. 6.

  62. N. Cyril, J. B. George, L. Joseph, A. C. Raghavamenon, and V. P. Sylas (2019). Toxicol Res.8, 297.

    CAS  Google Scholar 

  63. J. Pei, B. Fu, L. Jiang, and T. Sun (2019). Int J Nanomedicine.14, 1969.

    CAS  PubMed  PubMed Central  Google Scholar 

  64. R. Vijayan, S. Joseph, and B. Mathew (2019). Bioprocess Biosyst Eng.42, 305.

    CAS  PubMed  Google Scholar 

  65. C. T. Laurencin, S. G. Kumbar, and S. P. Nukavarapu (2009). Wiley Interdiscip Rev Nanomed Nanobiotechnol.1, 6.

    CAS  PubMed  Google Scholar 

  66. G. Bao, S. Mitragotri, and S. Tong (2013). Annu Rev Biomed Eng.15, 253.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. D. E. Lee, H. Koo, I. C. Sun, J. H. Ryu, K. Kim, and I. C. Kwon (2012). Chem Soc Rev.41, 2656.

    CAS  PubMed  Google Scholar 

  68. S. L. Smitha, K. M. Nissamudeen, D. Philip, and K. G. Gopchandran (2008). Spectrochim Acta A Mol Biomol Spectrosc.71, 186.

    CAS  PubMed  Google Scholar 

  69. H. Barabadi, F. Kobarfard, and H. Vahidi (2018). Iran J Pharm Res.17, 87.

    CAS  PubMed  PubMed Central  Google Scholar 

  70. L. C. Stoehr, E. Gonzalez, A. Stampfl, E. Casals, A. Duschl, V. Puntes, and G. J. Oostingh (2011). Part Fibre Toxicol.8, 36.

    CAS  PubMed  PubMed Central  Google Scholar 

  71. M. Naz, N. Nasiri, M. Ikram, M. Nafees, M. Z. Qureshi, S. Ali, and A. Tricoli (2017). Appl Nanosci.7, 793.

    CAS  Google Scholar 

  72. B. Buszewski, K. Rafiſska, P. Pomastowski, J. Walczak, and A. Rogowska (2016). Colloids Surf A Physicochem Eng Asp.506, 170.

    CAS  Google Scholar 

  73. A. Kaur, D. Goyal, and R. Kumar (2018). Appl Surf Sci.449, 23.

    CAS  Google Scholar 

  74. M. Saravanan, T. Asmalash, A. Gebrekidan, D. Gebreegziabiher, T. Araya, H. Hilekiros, H. Barabadi, and K. Ramanathan (2018). Pharm nanotechnol.6, 17.

    CAS  PubMed  Google Scholar 

  75. H. Barabadi (2017). Cell Mol Biol.63, 3.

    PubMed  Google Scholar 

  76. G. Venkatraman, P. Sakthimohan, V. Govindarajan, S. Muthupandian, and A. Davoodbasha Mubarak (2015). Pharma Nanotechnol.3, 26.

    Google Scholar 

Download references

Acknowledgements

This work was financially supported by Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant Number 18753).

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamed Barabadi

  2. Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Omid Hosseini

  3. Golestan University of Medical Sciences, Food and Drug Administration, Gorgan, Iran

    Kaveh Damavandi Kamali

  4. School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fereshteh Jazayeri Shoushtari

  5. Student Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

    Masoumeh Rashedi

  6. Drug and Advanced Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

    Hamed Haghi-Aminjan

  7. Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine,College of Health Sciences, Mekelle University, 1871, Mekelle, Ethiopia

    Muthupandian Saravanan

Authors
  1. Hamed Barabadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Omid Hosseini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kaveh Damavandi Kamali
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fereshteh Jazayeri Shoushtari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masoumeh Rashedi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hamed Haghi-Aminjan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Muthupandian Saravanan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Hamed Barabadi, Masoumeh Rashedi or Muthupandian Saravanan.

Ethics declarations

Conflict of interest

The authors declare no conflict of interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Barabadi, H., Hosseini, O., Damavandi Kamali, K. et al. Emerging Theranostic Silver Nanomaterials to Combat Lung Cancer: A Systematic Review. J Clust Sci 31, 1–10 (2020). https://doi.org/10.1007/s10876-019-01639-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10876-019-01639-z

Keywords

Search

Navigation