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Synthesis of a Novel Mesoporous Carbon Nanocube@Mesoporous Silica@Poly(acrylic acid) Composite and Application As Potential Drug Carriers

  • PHYSICAL CHEMISTRY OF NANOCLUSTERS AND NANOMATERIALS
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Abstract

The mesoporous carbon nanocube@mesoporous silica (mCNC@mSiO2) has a potential application as drug carriers because of its large surface area and low toxicity and biocompatibility. Hence, a novel double mesoporous material of mCNC@mSiO2 was prepared via a soft-template method. The mCNC@mSiO2 exhibited a uniform cubic morphology with large surface area of 545.9 m2 g–1 and average pore size of 7.94 nm. The drug capacity for mCNC@mSiO2 was 0.78 mg at concentration of 0.5 mg/mL for 24 h loading. Furthermore, after modified by poly(acrylic acid) (PAA), the mCNC@mSiO2@PAA drug capacity had changed from 0.78 to 1.009 mg at the same concentration as a cancer drug carrier due to electrostatic interaction between carboxyl and 5-fluorourail (5-Fu). The findings may show potential for MOF-derived carbon materials for bioscience applications.

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FUNDING

This work was supported by Hunan Province Science and Technology Project of China under grant no. 2014FJ3076.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China

    Xiao Song, Lan Hu, Xinjie Pang & Sufang Li

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  1. Xiao Song
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  2. Lan Hu
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  3. Xinjie Pang
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  4. Sufang Li
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Correspondence to Sufang Li.

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Xiao Song, Hu, L., Pang, X. et al. Synthesis of a Novel Mesoporous Carbon Nanocube@Mesoporous Silica@Poly(acrylic acid) Composite and Application As Potential Drug Carriers. Russ. J. Phys. Chem. 93, 1349–1356 (2019). https://doi.org/10.1134/S003602441907029X

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  • DOI: https://doi.org/10.1134/S003602441907029X

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