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Microstructural properties of trabecular bone autografts: comparison of men and women with and without osteoporosis

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Abstract

Summary

The microstructure of autologous bone grafts from men over 50 years old and postmenopausal women undergoing spinal fusion were evaluated using micro-CT. We demonstrated postmenopausal women, especially those with osteoporosis (OP) presented more serious microarchitectural deterioration of bone grafts.

Purpose

This study was undertaken to determine microstructural properties of cancellous bone used as autologous bone grafts from osteoporosis patients undergoing lumbar fusion by comparing microstructural indices to controls.

Methods

Cancellous bone specimens from spinous processes were obtained from 41 postmenopausal women (osteoporosis women, n = 19; controls, n = 22) and 26 men over 50 years old (osteoporosis men, n = 8; controls, n = 18) during lumbar fusion surgery. The microstructural parameters were measured using micro-CT.

Results

Significant difference in bone volume fraction (BV/TV), specific bone surface (BS/BV), trabecular thickness (Tb.Th), and structure model index (SMI) value existed between postmenopausal women with OP and controls. Significant difference in trabecular number (Tb.N) existed between men over 50 years old with OP and controls. Postmenopausal women exhibited lower BV/TV, Tb.Th, and higher SMI value than men over 50 years old. Postmenopausal women with OP exhibited lower BV/TV, Tb.Th, and higher BS/BV than men over 50 years old with OP.

Conclusions

Post-menopausal women and older men with OP have worse bone quality in autografts than non-osteoporotic men and women. Postmenopausal women with OP presented serious microarchitectural deterioration in older population

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Acknowledgements

This study was supported by grants from National Natural Science Foundation of China (81670804) and National Development and Reform Commission Foundation of Hunan Province (20131199).

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, National Clinical Research Center for Metabolic Disease, The Second XiangYa Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China

    Fen Xie, Jian Wang, Xiyu Wu & Ruchun Dai

  2. Department of Spine Surgery, The Second XiangYa Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China

    Bin Zhou & Yijun Kang

  3. Department of Orthopaedics, The Second XiangYa Hospital, Central South University, 139 Renmin Middle Road, Changsha, 410011, China

    Tang Liu & Rui Fang

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  1. Fen Xie
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  2. Bin Zhou
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  3. Jian Wang
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  4. Tang Liu
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  7. Yijun Kang
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  8. Ruchun Dai
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Corresponding authors

Correspondence to Yijun Kang or Ruchun Dai.

Ethics declarations

This study was approved by the medical ethics committee of the Second Xiangya Hospital of Central South University in China. All patients were informed and written consents of donating their bone samples were obtained.

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Xie, F., Zhou, B., Wang, J. et al. Microstructural properties of trabecular bone autografts: comparison of men and women with and without osteoporosis. Arch Osteoporos 13, 18 (2018). https://doi.org/10.1007/s11657-018-0422-z

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