Abstract
Cisplatin (CP) is a highly effective chemotherapeutic agent against neoplasms, but its clinical utility is limited due to the side effects of its dose-dependent nephrotoxicity. Vitamin E (Vit E) and cod liver oil (CLO) are natural substances with chemoprotective effects. The present study was conducted to evaluate the protective effects of Vit E and/or CLO for CP-induced acute kidney injury (AKI) in rats. This study involved 40 mature male Wistar albino rats that were equally allocated into eight groups: Veh, Vit E, CLO, Vit E + CLO, CP, Vit E + CP, CLO + CP, and Vit E + CLO + CP. The co-administration of Vit E and CLO significantly ameliorated CP-induced elevations in serum creatinine (Cr), blood urea nitrogen (BUN), interleukin 1 beta (IL-1β), and interleukin- 6 (IL-6). Further, rats that received Vit E and/or CLO showed significant decrease in malondialdehyde (MDA) and increases in superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) levels in renal tissues, compared to CP-intoxicated rats. Additionally, the treatment restored the normal histological architecture (except for few cast formations) and upregulated the immunostaining area% of aquaporin 3 (AQP3) and downregulated the immunostaining area% of Bcl2 associated X protein (BAX) and inducible nitric oxide synthase (iNOS). The observed effects were stronger in the combination treatment group. The obtained data revealed that Vit E and CLO co-administration protects against the CP-induced AKI more than monotherapy with Vit E or CLO.
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Abbreviations
- AKI:
-
Acute kidney injury
- BAX:
-
Bcl2-associated X protein
- BW:
-
Body weight
- BW/KW:
-
Body weight/kidney weight
- EPA:
-
Eicosapentaenoic acid
- IL-1β:
-
Interleukin 1 beta
- IL-6:
-
Interleukin-6
- Vit E:
-
Vitamin E
- CP:
-
Cisplatin
- CLO:
-
Cod liver oil
- CAT:
-
Catalase
- DHA:
-
Docosahexaenoic acid
- GSH:
-
Glutathione
- KW:
-
Kidney weight
- ROS:
-
Reactive oxygen species
- PUFAs:
-
Polyunsaturated Fatty Acids
- Cr:
-
Creatinine
- BUN:
-
Blood urea nitrogen
- MDA:
-
Malondialdehyde
- SOD:
-
Super oxide dismutase
- H&E:
-
Hematoxylin and eosin
- PAS:
-
Periodic acid-Schiff
- AQP3:
-
Aquaporin 3
- iNOS:
-
Inducible nitric oxide synthase
- Veh:
-
Vehicle
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This work was supported by King Saud University, Deanship of Scientific Research, College of Science Research Center.
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This work was supported by King Saud University, Deanship of Scientific Research, College of Science Research Center.
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Abo-Elmaaty, A.M.A., Behairy, A., El-naseery, N.I. et al. The protective efficacy of vitamin E and cod liver oil against cisplatin-induced acute kidney injury in rats. Environ Sci Pollut Res 27, 44412–44426 (2020). https://doi.org/10.1007/s11356-020-10351-9
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DOI: https://doi.org/10.1007/s11356-020-10351-9