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The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex

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Abstract

This study presents neuroprotective effects of fish n-3 EFA on the prefrontal cortex after cerebral ischemia and reperfusion. Eighteen rats divided into three groups. Group A rats were used as control. Cerebral ischemia and reperfusion was produced in rats either on a standard diet (Group B) or a standard diet plus fish n-3 EFA for 14 days (Group C). The malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and catalase (CAT) were measured and the number of apoptotic neurons was counted. The levels of MDA and activities of SOD increased in Group B rats as compared to Group A rats, and decreased in Group C rats as compared to Group B rats. The activities of CAT increased in Group C as compared to Group B rats. The number of apoptotic neurons in the prefrontal cortex was lower in Group C as compared to Group B rats.

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Authors and Affiliations

  1. School of Medicine Department of Anatomy, Kocatepe University, Afyonkarahisar, Turkey

    Oguz Aslan Ozen, Ozan Alkoc & Ahmet Songur

  2. School of Medicine, Department of Neurosurgery, Canakkale 18 March University, Canakkale, Turkey

    Murat Cosar

  3. School of Medicine Department of Pathology, Kocatepe University, Afyonkarahisar, Turkey

    Onder Sahin

  4. School of Medicine Department of Anesthesiology, Kocatepe University, Afyonkarahisar, Turkey

    Huseyin Fidan

  5. School of Medicine Department of Biophysics, Kocatepe University, Afyonkarahisar, Turkey

    Hakan Mollaoglu

  6. School of Medicine Department of Neurology, Kocatepe University, Afyonkarahisar, Turkey

    Olcay Eser & Mehmet Yaman

Authors
  1. Oguz Aslan Ozen
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  2. Murat Cosar
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  3. Onder Sahin
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  4. Huseyin Fidan
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  5. Olcay Eser
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  6. Hakan Mollaoglu
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  7. Ozan Alkoc
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  8. Mehmet Yaman
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  9. Ahmet Songur
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Correspondence to Murat Cosar.

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Ozen, O.A., Cosar, M., Sahin, O. et al. The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex. Neurol Sci 29, 147–152 (2008). https://doi.org/10.1007/s10072-008-0926-1

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  • DOI: https://doi.org/10.1007/s10072-008-0926-1

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