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Bovine mastitis prevention and control in the post-antibiotic era

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Abstract

Mastitis is the most important disease in the dairy industry. Antibiotics are considered to be the first choice in the treatment of the disease. However, the problem of antibiotic residue and antimicrobial resistance, in addition to the impact of antibiotic abuse on public health, leads to many restrictions on uncontrolled antibiotic therapy in the dairy sector worldwide. Researchers have investigated novel therapeutic approaches to replace the use of antibiotics in mastitis control. These efforts, supported by the revolutionary development of nanotechnology, stem cell assays, molecular biological tools, and genomics, enabled the development of new approaches for mastitis-treatment and control. The present review discusses recent concepts to control mastitis such as breeding of mastitis-resistant dairy cows, the development of novel diagnostic and therapeutic tools, the application of communication technology as an educational and epidemiological tool, application of modern mastitis vaccines, cow drying protocols, teat disinfection, housing, and nutrition. These include the application of nanotechnology, stem cell technology, photodynamic and laser therapy or the use of traditional herbal medical plants, nutraceuticals, antibacterial peptides, bacteriocins, antibodies therapy, bacteriophages, phage lysins, and probiotics as alternatives to antibiotics.

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  1. Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

    Amr El-Sayed & Mohamed Kamel

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Mohamed Kamel and Amr El-Sayed wrote and drafted the manuscript, critically revised the manuscript and approved the final manuscript.

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Highlights

1. Nanotechnology use in mastitis diagnosis and control

2. Alternative therapeutic concepts as replacers to antibiotics

3. Improvement of management concepts and mastitis control

4. Vaccines and immunomodulators lead to mastitis control

5. Mastitis-resistant cows for mastitis control

This article belongs to the Topical Collection Dairy Science and Health in the Tropics

Mohamed Kamel and Amr El-Sayed contributed equally to this work

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El-Sayed, A., Kamel, M. Bovine mastitis prevention and control in the post-antibiotic era. Trop Anim Health Prod 53, 236 (2021). https://doi.org/10.1007/s11250-021-02680-9

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