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Pharmacologically active hydrogels derived from silicon glycerolates and chitosan

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Abstract

Novel hybrid chitosan-containing hydrogels were obtained from various functionalized silicon glycerolates by the sol—gel method. According to SEM images of aerogels prepared by supercritical drying in liquid CO2, chitosan serves as a template in the structuring of hybrid hydrogels. The hydrogels obtained are nontoxic, exhibit pronounced hemostatic activity, and are promising for medical use.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620137, Ekaterinburg, Russian Federation

    E. Yu. Larchenko, T. G. Khonina, E. V. Shadrina, A. V. Pestov & O. N. Chupakhin

  2. First President of Russia B. N. El’tsin Ural Federal University, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    O. N. Chupakhin

  3. D. I. Mendeleev University of Chemical Technology of Russia, 20 ul. Geroev Panfilovtsev, 125480, Moscow, Russian Federation

    N. V. Menshutina, A. E. Lebedev & D. D. Lovskaya

  4. Ural State Medical University of the Ministry of Health of the Russian Federation, 3 ul. Repina, 620219, Ekaterinburg, Russian Federation

    L. P. Larionov & S. A. Chigvintsev

Authors
  1. E. Yu. Larchenko
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  2. T. G. Khonina
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  3. E. V. Shadrina
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  4. A. V. Pestov
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  5. O. N. Chupakhin
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  6. N. V. Menshutina
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  7. A. E. Lebedev
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  8. D. D. Lovskaya
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  9. L. P. Larionov
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  10. S. A. Chigvintsev
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Corresponding author

Correspondence to E. Yu. Larchenko.

Additional information

Based on the materials of the First Russian Conference on Medicinal Chemistry (“MedChem Russia-2013”) with International Participation (September 8–12, 2013, Moscow).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1225–1231, May, 2014.

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Larchenko, E.Y., Khonina, T.G., Shadrina, E.V. et al. Pharmacologically active hydrogels derived from silicon glycerolates and chitosan. Russ Chem Bull 63, 1225–1231 (2014). https://doi.org/10.1007/s11172-014-0578-7

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  • DOI: https://doi.org/10.1007/s11172-014-0578-7

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