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Synthesis of hydrogels based on silicon polyolates

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Abstract

Biologically active hydrogels based on silicon polyolates, which are the products of reactions of tetraethoxy- and methyltriethoxysilanes with polyols (1,2-propanediol, glycerol, polyethylene glycol), were synthesized. The optimal conditions for hydrogel formation and hydrogel composition were determined. The acute toxicity and transcutaneous and wound-healing activities of the synthesized compounds were studied. The experimental results show that hydrogels based on silicon polyolates can be recommended for further preclinical and clinical tests with the purpose of their use in medical practice both as self-sufficient agents and ointment bases of pharmaceutical compositions with wound-healing, regenerative, and transcutaneous action.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoy, 620041, Ekaterinburg, Russian Federation

    T. G. Khonina, E. V. Shadrina, A. A. Boyko & O. N. Chupakhin

  2. Ural State Medical Academy of the Federal Agency on the Health Care and Social Development of Russia, 3 ul. Repina, 620219, Ekaterinburg, Russian Federation

    L. P. Larionov, A. A. Volkov & V. D. Burda

Authors
  1. T. G. Khonina
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  2. E. V. Shadrina
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  3. A. A. Boyko
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  4. O. N. Chupakhin
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  5. L. P. Larionov
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  6. A. A. Volkov
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  7. V. D. Burda
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Corresponding author

Correspondence to T. G. Khonina.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 76–81, January, 2010.

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Khonina, T.G., Shadrina, E.V., Boyko, A.A. et al. Synthesis of hydrogels based on silicon polyolates. Russ Chem Bull 59, 75–80 (2010). https://doi.org/10.1007/s11172-010-0047-x

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  • DOI: https://doi.org/10.1007/s11172-010-0047-x

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