Skip to main content

Advertisement

SpringerLink
Log in

Synthesis, toxicity, and percutaneous activity of silicon glycerolates and related hydrogels

  • Search for New Drugs
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Silicon glycerolates of the general formula Si(C3H7O3)4 ⋅ xC3H8O3(3 ≤ x ≤ 10) and related hydrogels of the general formula Si(C3H7O3)4 ⋅ xC3H8O3 ≤ yH2O (3 ≤ x ≤ 10, 20 ≤ y ≤ 40) were synthesized and some of their pharmacological properties were studied. The laws of gel formation were investigated and optimum conditions for the process were determined. High percutaneous (transdermal) activity of the synthesized compounds was revealed by measuring the diffusion of drugs through intact skin membrane in vitro. The acute and chronic toxicity was studied. It was established that all substances are nontoxic. The experimental results show that silicon glycerolates and related hydrogels can be recommended for further testing and investigation as effective biologically active percutaneous vehicles of medicinal preparations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. T. Chizhova and G. V. Mikhailova, Medicinal and Therapeutic-Cosmetic Ointments [in Russian], VUNMTs, Moscow (1999).

    Google Scholar 

  2. M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2005), p. 108.

    Google Scholar 

  3. RF Pat. No. 2,165,265 (2001).

  4. RF Pat. No. 1,838,318 (1993); Ref. Zh. Khim., 10 O76 P (1994).

  5. M. G. Voronkov, G. I. Zelchan, and E. Ya. Lukevits, Silicon and Life. Biochemistry, Pharmacology, and Toxicology of Silicon Compounds [in Russian], Zinatne, Riga (1978).

    Google Scholar 

  6. E. Ya. Lukevits and Z. A. Zelme, Biological Activity of Silicon Compounds [in Russian], Zinatne, Riga (1984).

    Google Scholar 

  7. T. G. Boyakovskaya, T. G. Khonina, L. P. Larionov, et al., New Materials for Medicine [in Russian], Ural Branch, RAS, Yekaterinburg (2006), pp. 108–135.

    Google Scholar 

  8. RF Pat. No. 2,255,939 (2005); Ref. Zh. Khim., 05.23–19O.219 P (2005).

    Google Scholar 

  9. T. G. Khonina, N. A. Kochneva, and A. L. Suvorov, Zh. Obshch. Khim., 67(1), 84–87 (1997).

    Google Scholar 

  10. Yu. G. Yatluk, E. A. Khrustaleva, I. A. Sorokina, and R. S. Barshtein, Titanium-Containing Compounds, Catalysts of Polycondensation Processes. Review Information [in Russian], NIITEKhIM, Moscow (1990).

    Google Scholar 

  11. M. G. Voronkov, V. P. Mileshkevich, and Yu. A. Yuzhelevskii, Siloxane Bond [in Russian], Nauka, Novosibirsk (1976).

    Google Scholar 

  12. R. U. Khabriev, ed., Handbook of Experimental (Preclinical) Study of New Drugs [in Russian], ZAO IIA (Premidium), Moscow (2000).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

    T. G. Khonina, O. N. Chupakhin, A. L. Suvorov & E. V. Shadrina

  2. Ural State Medical Academy, Yekaterinburg, Russia

    L. P. Larionov & T. G. Boyakovskaya

Authors
  1. T. G. Khonina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. N. Chupakhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. P. Larionov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. G. Boyakovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. L. Suvorov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. V. Shadrina
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 11, pp. 5–9, November, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khonina, T.G., Chupakhin, O.N., Larionov, L.P. et al. Synthesis, toxicity, and percutaneous activity of silicon glycerolates and related hydrogels. Pharm Chem J 42, 609–613 (2008). https://doi.org/10.1007/s11094-009-0199-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-009-0199-x

Keywords

Search

Navigation