Abstract
New 4-(2-hydroxymethylaryl)coumarins were prepared using the Suzuki—Miyaura cross-coupling at the key step. According to X-ray diffraction data, the compounds obtained are structural analogs of the natural stilbene combretastatin A-4, which exhibits potent antitumor activity.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 612–617, March, 2010.
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Sitnikov, N.S., Shavyrin, A.S., Fukin, G.K. et al. Synthesis of 4-(2-hydroxymethylaryl)coumarins. Russ Chem Bull 59, 626–631 (2010). https://doi.org/10.1007/s11172-010-0130-3
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DOI: https://doi.org/10.1007/s11172-010-0130-3