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Synthesis and antiproliferative activity of 6,7-aryl/hetaryl coumarins

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Abstract

Two different series of novel analogs of 6,7-aryl/hetaryl coumarins 4a–4h and 8i–8l have been synthesized by using Suzuki–Miyara cross coupling reaction from 4-methyl-2-oxo-2H-chromen-7-yl trifluoro-methanesulfonate and 4-methyl-2-oxo-2H-chromen-6-yl trifluoromethanesulfonate in high yields (70–90%). All synthesized compounds were elucidated by means of IR, 1H NMR, 13C NMR, and MS spectra. The synthesized compounds were tested for antiproliferative activity against different human cancer cell lines (SiHa, MDAMB-231, and PANC-1) and some of products demonstrated the distinctive effect.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Y. Jayaprakash Rao & E. Yadaiah goud

  2. Department of Chemistry, Telangana University, Nizamabad, 503322, India

    Y. Jayaprakash Rao

  3. Department of Chemistry, Nizam College, Osmania University, Osmania, 500001, India

    Y. Hemasri

  4. Center for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India

    Nishant Jain & Srujana Gabriella

Authors
  1. Y. Jayaprakash Rao
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  2. E. Yadaiah goud
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  3. Y. Hemasri
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  4. Nishant Jain
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  5. Srujana Gabriella
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Correspondence to E. Yadaiah goud.

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The text was submitted by the authors in English.

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Jayaprakash Rao, Y., Yadaiah goud, E., Hemasri, Y. et al. Synthesis and antiproliferative activity of 6,7-aryl/hetaryl coumarins. Russ J Gen Chem 86, 184–189 (2016). https://doi.org/10.1134/S1070363216010291

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  • DOI: https://doi.org/10.1134/S1070363216010291

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