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Synthesis of 6-(3-Pyrazolyl)-4-Methylumbelliferone Derivatives Substituted on the Pyrazole Ring

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Chemistry of Natural Compounds Aims and scope

A two-step synthesis of 6-(3-pyrazolyl)coumarins starting from 7-hydroxy(acetoxy)chromones was developed. It included their recyclization using hydrazine hydrate into 4-(3-pyrazolyl)-1,3-benzenediols followed by condensation with acetoacetic ester to produce 6-(3-pyrazolyl)-4-methylumbelliferone derivatives with aryl, aryloxy, and hetaryl substituents on the pyrazole ring.

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Authors and Affiliations

  1. Taras Shevchenko Kiev National University, 01033, Kiev, Ul. L. Tolstogo, 12, Ukraine

    T. V. Shokol, N. V. Gorbulenko & V. P. Khilya

  2. Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, 02660, Kiev, -94, Ul. Murmanskaya, 1, Ukraine

    M. S. Frasinyuk

Authors
  1. T. V. Shokol
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  2. N. V. Gorbulenko
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  3. M. S. Frasinyuk
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  4. V. P. Khilya
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Correspondence to T. V. Shokol.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2015, pp. 545–547.

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Shokol, T.V., Gorbulenko, N.V., Frasinyuk, M.S. et al. Synthesis of 6-(3-Pyrazolyl)-4-Methylumbelliferone Derivatives Substituted on the Pyrazole Ring. Chem Nat Compd 51, 630–633 (2015). https://doi.org/10.1007/s10600-015-1371-z

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  • DOI: https://doi.org/10.1007/s10600-015-1371-z

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