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DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case–control studies

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An Erratum to this article was published on 16 March 2012

Abstract

The association between polymorphism of DNA methyltransferases 3B and cancer risk has been widely studied recently, and no consensus conclusion is available up to now. We perform a comprehensive search using the databases of Medline, ISI Web of Knowledge and Embase. The odds ratio (OR) and its 95% confidence interval (95% CI) are used to investigate the strength of the association. A total of 24 case–control studies with 15,647 individuals are included in this meta-analysis. For −149C > T (17 studies, 5229 cases and 6910 controls), no evidence indicate that individuals carrying the variant genotypes (CC + CT), relative to those carrying the wild homozygote TT genotype, have an increased risk of cancer (OR = 1.03; 95% CI = 0.84–1.26; P = 0.76). Similarly, no cancer risk is found in the subgroup analyses. For −579G > T (11 studies, 3513 cases and 3714 controls), significantly decreased risks of cancer are observed, and the ORs (95% CI) are 0.70 (0.56–0.87) for GT versus TT, 0.70 (0.57–0.85) for GG + GT versus TT and 0.76 (0.63–0.93) for G-allele versus T-allele, respectively. Subgroup analyses stratified by ethnicity and types of cancer are also performed, and results indicated that −579G > C polymorphism is associated with risk of cancer in Asians [0.68 (0.53–0.87) for GT vs. TT] but not in Europeans [0.82 (0.63–1.07) for GT vs. TT]. We also observe that the −579G is associated with decreased risk of colorectal cancer [0.49(0.38–0.62) for GT vs. TT]. More studies with larger sample size were needed to provide more precise evidence.

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Acknowledgments

We thank all authors of primary studies included in our meta-analyses. There was no funding support. There is no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Urology, The 2nd Hospital of Tianjin Medical University, and Tianjin Institute of Urology, Pingjiang road 23, Hexi District, Tianjin, 300211, China

    Shimiao Zhu, Yang Tang & Jianmin Wang

  2. General Department, Beijing Friendship Hospital of Capital Medical University, Yong’an road 95, Beijing, 100050, China

    Hui Zhang

  3. Department of Stomatology, The 2nd Hospital of Tianjin Medical University, Pingjiang road 23, Hexi District, Tianjin, 300211, China

    Peicai Liu

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  1. Shimiao Zhu
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  2. Hui Zhang
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Corresponding author

Correspondence to Jianmin Wang.

Additional information

S. Zhu and H. Zhang contributed equally to this work.

An erratum to this article can be found at http://dx.doi.org/10.1007/s11033-012-1617-9.

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Zhu, S., Zhang, H., Tang, Y. et al. DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case–control studies. Mol Biol Rep 39, 4429–4437 (2012). https://doi.org/10.1007/s11033-011-1231-2

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  • DOI: https://doi.org/10.1007/s11033-011-1231-2

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