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Compatibility studies of trioxsalen with excipients by DSC, DTA, and FTIR

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Abstract

Psoralens are widely used for the treatment of psoriasis. Trioxsalen is a drug prescribed low-dose, belonging to the group of substituted psoralen. The aim of this study was to evaluate the compatibility of trioxsalen with pharmaceutical excipients used in the solid forms by analytical techniques. Binary mixtures between the trioxsalen and pharmaceutical excipients (namely, magnesium stearate, α-lactose, microcrystalline cellulose 102, pregelatinized starch, mannitol, sodium lauryl sulfate, sodium starch glycolate, and croscarmellose sodium) were examined. The trioxsalen–sodium lauryl sulfate mixture displayed some physical interaction based on the DTA and DSC results, but the FTIR study ruled out any chemical change.

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Acknowledgments

The authors thank Fundação de Apoio à Pesquisa do Estado do Rio Grande do Norte (FAPERN), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for financial support and Laboratório de Certificação de Biomateriais (CERTBIO).

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Authors and Affiliations

  1. Programa de Pós-graduação em Desenvolvimento e Inovação Tecnológica em Medicamentos, Universidade Federal do Rio Grande do Norte, Caixa Postal 1524, Campus Universitário, Lagoa Nova, Natal, RN, 59078-970, Brazil

    Naiana G. P. B. Lima, Igor P. B. Lima, Denise M. C. Barros, Thays S. Oliveira, Fernanda N. Raffin, Túlio F. A. de Lima e Moura, Ana P. B. Gomes & Cícero F. S. Aragão

  2. Laboratório de Desenvolvimento e Ensaios de Medicamentos, Universidade Estadual da Paraíba, Centro de Ciências Biológicas e da Saúde, Campina Grande, PB, 58.429-500, Brazil

    Naiana G. P. B. Lima & Ana C. D. Medeiros

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  1. Naiana G. P. B. Lima
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Correspondence to Cícero F. S. Aragão.

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Lima, N.G.P.B., Lima, I.P.B., Barros, D.M.C. et al. Compatibility studies of trioxsalen with excipients by DSC, DTA, and FTIR. J Therm Anal Calorim 115, 2311–2318 (2014). https://doi.org/10.1007/s10973-013-3216-y

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