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Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods

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Abstract

The compatibility of aceclofenac with various tableting excipients was investigated by means of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The excipients applied in the direct pressing retard tablets were Carbopol 940, hydroxypropyl-methyl-cellulose, microcrystalline cellulose, Aerosil 200 and magnesium stearate. The ingredients alone and their 1:1 (w/w) binary mixtures were investigated before and after accelerated storage. An interaction was observed only between aceclofenac and magnesium stearate. The DSC and FT-IR examinations indicated formation of the magnesium salt of aceclofenac. For the other mixtures, there was no incompatibility between the components.

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Acknowledgements

This work was supported by a TÁMOP research project: development of teranostics in cardiovascular, metabolics and inflammatory diseases (TÁMOP-4.2.2-08/1-2008-0013).

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary

    Z. Aigner, G. Farkas & P. Szabó-Révész

  2. Department of Pharmaceutical Technology, University of Medicine and Pharmacy of Târgu Mures, Marinescu Str. 38, 540139, Targu-Mures, Romania

    R. Heinrich, E. Sipos & A. Ciurba

  3. Department of Physical Chemistry and Materials Science, University of Szeged, Aradi Vértanúk tere 1, Szeged, H-6720, Hungary

    O. Berkesi

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  1. Z. Aigner
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  2. R. Heinrich
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  3. E. Sipos
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  4. G. Farkas
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  7. P. Szabó-Révész
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Correspondence to Z. Aigner.

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Aigner, Z., Heinrich, R., Sipos, E. et al. Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods. J Therm Anal Calorim 104, 265–271 (2011). https://doi.org/10.1007/s10973-010-1105-1

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  • DOI: https://doi.org/10.1007/s10973-010-1105-1

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