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Comparative kinetic study of decomposition of some diazepine derivatives under isothermal and non-isothermal conditions

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Abstract

Thermal analysis is one of the most widely used methods for studying the solid state of pharmaceutical substances.

TG/DTG and DSC curves provide important information regarding the physical properties of the pharmaceutical compounds (stability, compatibility, polymorphism, kinetic analysis, phase transitions etc.).

The purpose of a kinetic investigation is to calculate the kinetic parameters and the kinetic model for the studied process. The results are further used to predict the system’s behaviour in various circumstances.

A kinetic study regarding the diazepam, nitrazepam and oxazepam thermal decomposition was performed, under non-isothermal and isothermal conditions and in a nitrogen atmosphere, for the temperature steps: 483, 498, 523, 538 and 553 K. The TG/DTG data were processed by three methods: isothermal model-fitting, Friedman’s isothermal-isoconversional and Nomen-Sempere non-parametric kinetics.

In the model-fitting methods the kinetic triplets (f(α), A and E a) that defines a single reaction step resulted in being at variance with the multi-step nature of diazepines decomposition. The model-free approach represented by isothermal and non-isothermal isoconversional methods, gave dependences of the activation energies on the extent of conversion.

It is very difficult to obtain an accord with the similar data which resulted under non-isothermal conditions from a previous work.

The careful treatment of the kinetic parameters obtained in different thermal conditions was confirmed to be necessary, as well as a different strategy of experimental data processing.

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Authors and Affiliations

  1. Faculty of Pharmacy, ’Victor Babeş’ University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041, Timişoara, România

    B. Tiţa & D. Tiţa

  2. Faculty of Medicine and Pharmacy, Oradea University, Speciality of Pharmacy, Nicolae Jiga Street, No. 29, Oradea, România

    Eleonora Marian

  3. Faculty of Chemistry-Biology-Geography, West University of Timişoara, Pestalozzi Street, No. 16, Timişoara, 300115, România

    Gabriela Vlase, N. Doca & T. Vlase

Authors
  1. B. Tiţa
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  2. Eleonora Marian
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  3. D. Tiţa
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  4. Gabriela Vlase
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  5. N. Doca
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  6. T. Vlase
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Correspondence to B. Tiţa.

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Tiţa, B., Marian, E., Tiţa, D. et al. Comparative kinetic study of decomposition of some diazepine derivatives under isothermal and non-isothermal conditions. J Therm Anal Calorim 94, 447–452 (2008). https://doi.org/10.1007/s10973-008-9146-4

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  • DOI: https://doi.org/10.1007/s10973-008-9146-4

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