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Differential scanning microcalorimetry study of thermal stability of nevirapine and azidothymidine mixture

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Abstract

A differential scanning calorimetry study of the thermal behavior of nevirapine and azidothymidine in water solution was carried out. For nevirapine scan rate dependent and irreversible endothermic peak were found. Thermal degradation of nevirapine as well as NVP – AZT mixture is relatively well described by the model involving only one irreversible step determined by a first-order rate constant. The estimated kinetic constants and activation energies indicate that the degradation process proceeds slower for nevirapine in presence of AZT ligands than without them.

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Authors and Affiliations

  1. University of Silesia, A. Chełkowski’ Institute of Physics, Department of Medical Physics, Katowice, Poland, 40–007, Ul. Uniwersytecka 4

    Michalik K., Drzazga Zofia & Michnik Anna

  2. Medical University of Silesia, Department of Conservative and Peropdontology, Bytom, Poland, 41-902, Pl. Akademicki 17

    Kaszuba M.

Authors
  1. Michalik K.
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  2. Drzazga Zofia
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  3. Michnik Anna
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  4. Kaszuba M.
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Correspondence to Drzazga Zofia.

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Michalik, K., Drzazga, Z., Michnik, A. et al. Differential scanning microcalorimetry study of thermal stability of nevirapine and azidothymidine mixture. J Therm Anal Calorim 84, 119–123 (2006). https://doi.org/10.1007/s10973-005-7171-0

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  • DOI: https://doi.org/10.1007/s10973-005-7171-0

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