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Thermoanalytical investigation of drug–excipient interaction

Part II. Activated mixtures of piroxicam with cellulose and chitosan

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Abstract

Piroxicam–excipient (chitosan or cellulose) mixtures after mechanical activation were investigated using DSC. Crystallization of amorphous piroxicam was detected near 80°C in the mixtures of the components activated separately. If the components in the mixture are activated together, amorphous piroxicam does not crystallize at heating.

Both excipients interact with piroxicam, decreasing its melting point and enthalpy of melting. Mechanical activation intensifies the interaction, decreasing the melting point by 8°C and reducing the enthalpy of melting two times.

Both excipients interact identically with piroxicam, affecting identically its melting parameters. Nevertheless, the two excipients affect its solubility in water very differently. Cellulose does not change the solubility, but chitosan increases it ten times. The mechanism of piroxicam dissolution from the mixture with an excipient is discussed.

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Authors and Affiliations

  1. ‘Molecular Design and Ecologically Safe Technologies’ REC-008, Novosibirsk State University, Novosibirsk, Russia, 630090, Ul. Pirogova 2

    Tatyana P. Shakhtshneider & Svetlana A. Apenina

  2. Institute of Mineralogy and Petrography SB RAS, Novosibirsk, Russia, 630090, Pr. Ac. Koptyuga 3

    V. A. Drebushchak

  3. Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, Russia, 630128, Ul. Kutateladze 3

    V. V. Boldyrev

  4. A. E. Favorsky Irkutsk Institute of Chemistry, SB RAS, Irkutsk, Russia, 664033, Ul. Favorskogo, 1

    Alevtina S. Medvedeva & Líubov’ P. Safronova

Authors
  1. V. A. Drebushchak
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  2. Tatyana P. Shakhtshneider
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  3. Svetlana A. Apenina
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  4. Alevtina S. Medvedeva
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  5. Líubov’ P. Safronova
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  6. V. V. Boldyrev
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Correspondence to V. A. Drebushchak.

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Drebushchak, V., Shakhtshneider, T., Apenina, S. et al. Thermoanalytical investigation of drug–excipient interaction. J Therm Anal Calorim 86, 303–309 (2006). https://doi.org/10.1007/s10973-005-7440-y

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  • DOI: https://doi.org/10.1007/s10973-005-7440-y

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