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The graft copolymerization of N-vinyl-2-pyrrolidone onto carboxymethyl cellulose and its application for controlled release of water-soluble levofloxacin

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Abstract

The N-vinyl-2-pyrrolidone-grafted-carboxymethylcellulose was synthesised by employing a free radical polymerization method in an N2 atmosphere. It was found that 0.661 g concentration of monomer was sufficient to afford the maximum grafting parameters viz. % grafting (%G), % efficiency (%E) % Add on (%A) % and conversion (%C), but these grafting indicators showed a decreasing trend with increasing the concentration of monomer from 0.661 g to 0.993 g. The prepared graft copolymer was characterized by FT-IR, 1H NMR, TGA/DTG, SEM, GPC and X-ray diffraction (XRD) analysis. The hybrid of the grafted CMC with the sodium alginate was prepared and used to study the loading and release of levofloxacin drug, about 70% loading of levofloxacin was observed and its 80% release was observed in phosphate buffer solution (PBS) at pH 7.4 & 37 °C in 30 h.

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Acknowledgements

The UGC New Delhi, Government of India are thankfully acknowledged for the financial support in the form of JRF-SRF fellowship to Ashok Kumar.

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  1. Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005 (UP), India

    Ashok Kumar, Swati Sharma & Rajesh Kumar

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  1. Ashok Kumar
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  2. Swati Sharma
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  3. Rajesh Kumar
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Correspondence to Rajesh Kumar.

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Kumar, A., Sharma, S. & Kumar, R. The graft copolymerization of N-vinyl-2-pyrrolidone onto carboxymethyl cellulose and its application for controlled release of water-soluble levofloxacin. J Polym Res 27, 46 (2020). https://doi.org/10.1007/s10965-020-2023-y

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