Skip to main content
SpringerLink
Log in

Comparison of O/W and IL/W Microemulsion Systems as Potential Carriers of Sparingly Soluble Celecoxib Drug

  • Published:
Journal of Solution Chemistry Aims and scope Submit manuscript

Abstract

Active pharmaceutical ingredients with poor solubility in water and some organic solvents are a challenge in the pharmaceutical industry. To overcome this limitation, microemulsion systems are a choice to increase the solubility of a sparingly soluble active ingredient. The purpose of this study is to introduce and compare two types of oil-in-water (O/W) and ionic liquid-in-water (IL/W) microemulsions, which were formulated to increase the solubility of celecoxib as an active pharmaceutical ingredient. The proposed formulations are composed of the same nonionic surfactant/co-surfactant of Tween-80/transcutol®P, and different oil phases of isopropyl myristate, [BMIM][PF6] and [OMIM][PF6]. The pseudo-ternary phase diagrams for the microemulsion systems have been determined at a surfactant-to-co-surfactant mass ratio of 3:1 and 298.15 K. From the microemulsion region of the phase diagrams, four formulations was selected and their physico-chemical properties as density, viscosity, refractive index, electrical conductivity and surface tension were measured at 298.15 K. The solubilities of celecoxib in all selected formulations were also determined and compared. The results show considerable increases in solubility of the celecoxib in the ionic liquid-based microemulsion systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Araya, H., Tomita, M., Hayashi, M.: The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int. J. Pharm. 305, 61–74 (2005)

    Article  CAS  Google Scholar 

  2. Lawrence, M.J., Rees, G.D.: Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 64, 175–193 (2012)

    Article  Google Scholar 

  3. Grampurohit, N., Ravikumar, P., Mallya, R.: Microemulsions for topical use: a review. Ind. J. Pharm. Edu. Res. 45, 100–107 (2011)

    Google Scholar 

  4. Salabat, A., Sanij, F.D.: Separation of two amino acids by microemulsion bulk liquid membrane. Bull. Korean Chem. Soc. 33, 3387–3390 (2012)

    Article  CAS  Google Scholar 

  5. Salabat, A., Saydi, H.: Microemulsion route to fabrication of silver and platinum–polymer nanocomposites. Polym. Compo 35, 2023–2028 (2014)

    Article  CAS  Google Scholar 

  6. Goindi, S., Arora, P., Kumar, N., Puri, A.: Development of novel ionic liquid-based microemulsion formulation for dermal delivery of 5-fluorouracil. AAPS PharmSciTech 15, 810–821 (2014)

    Article  CAS  Google Scholar 

  7. Kajbafvala, A., Salabat, A., Salimi, A.: Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. Pharm. Dev. Technol. 23, 741–750 (2018)

    Article  CAS  Google Scholar 

  8. Li, Q., Huang, X.: Formation of 1-butyl-3-methylimidazolium bis(2-ethyl-1-hexyl)sulfosuccinate stabilized water-in-1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide microemulsion and the effects of additives. J. Solution Chem. 46, 1792–1804 (2017)

    Article  CAS  Google Scholar 

  9. Kusano, T., Fujii, K., Hashimoto, K., Shibayama, M.: Water-in-ionic liquid microemulsion formation in solvent mixture of aprotic and protic imidazolium-based ionic liquids. Langmuir 30, 11890–11896 (2014)

    Article  CAS  Google Scholar 

  10. Mirhosseini, F., Salabat, A.: Ionic liquid based microemulsion method for fabrication of poly(methyl methacrylate)–TiO2 nanocomposite as highly efficient visible light photocatalyst. RSC Adv. 5, 12536–12545 (2015)

    Article  CAS  Google Scholar 

  11. Wang, X.G., Cheng, J.H., Ji, G.Y., Peng, X.C., Luo, Z.G.: Starch nanoparticles prepared in a two ionic liquid based microemulsion system and their drug loading and release properties. RSC Adv. 6, 4751–4757 (2016)

    Article  CAS  Google Scholar 

  12. Seddon, K.R.: Ionic liquids for clean technology. J. Chem. Technol. Biotechnol. 68, 351–356 (1997)

    Article  CAS  Google Scholar 

  13. Welton, T.: Room-temperature ionic liquids; solvents for synthesis and catalysis. Chem. Rev. 99, 2071–2084 (1999)

    Article  CAS  Google Scholar 

  14. Poh, Y., Ng, S., Ho, K.: Formulation and characterization of 1-ethyl-3-methylimidazolium acetate-in-oil microemulsions as the potential vehicle for drug delivery across the skin barrier. J. Mol. Liq. 273, 339–345 (2019)

    Article  CAS  Google Scholar 

  15. Goindi, S., Kaur, R., Kaur, R.: An ionic liquid-in-water microemulsion as a potential carrier for topical delivery of poorly water soluble drug: Development, ex-vivo and in-vivo evaluation. Int. J. Pharm. 495, 913–923 (2015)

    Article  CAS  Google Scholar 

  16. Subramanian, N., Ghosal, S.K., Moulik, S.P.: Topical delivery of celecoxib using microemulsion. Acta Pol. Pharm. 61, 335–341 (2004)

    PubMed  CAS  Google Scholar 

  17. Soltanpour, S., Mirzaei, A.: Theoretical and experimental solubility of celecoxib in binary and ternary solvents of polyethylene glycols 200, 400 or 600 with ethanol and water at 298.2 K. J. Solution Chem. 45, 1797–1810 (2016)

    Article  CAS  Google Scholar 

  18. Kajbafvala, A., Salabat, A.: A novel one-step microemulsion method for preparation of quercetin encapsulated poly(methyl methacrylate) nanoparticles. Iran. Polym. J. 26, 651–662 (2017)

    Article  CAS  Google Scholar 

  19. Salabat, A., Mirhoseini, F.: A novel and simple microemulsion method for synthesis of biocompatible functionalized gold nanoparticles. J. Mol. Liq. 268, 849–853 (2018)

    Article  CAS  Google Scholar 

  20. Salabat, A., Najafabadifarahani, S.: Physico-chemical evaluation of a biocompatible microemulsion system containing IPM/Tween80/isobutanol. Iran. Chem. Commun. 7, 134–141 (2019)

    CAS  Google Scholar 

  21. Salabat, A., Mirhoseini, F., Arjomandzadegan, M., Jiryaei, E.: A novel methodology for fabrication of Ag–polypyrrole core–Shell nanosphere using microemulsion system and evaluation of its antibacterial application. New J. Chem. 41, 12892–12900 (2017)

    Article  CAS  Google Scholar 

  22. Freire, M.G., Carvalho, P.J., Fernandes, A.M., Marrucho, I.M., Queimada, A.J., Coutinho, J.A.: Surface tensions of imidazolium based ionic liquids: Anion, cation, temperature and water effect. J. Colloid Interface Sci. 314, 621–630 (2007)

    Article  CAS  Google Scholar 

  23. Hunt, P.A.: Why does a reduction in hydrogen bonding lead to an increase in viscosity for the 1-butyl-2,3-dimethyl-imidazolium-based ionic liquids? J. Phys. Chem. B 111, 4844–4853 (2007)

    Article  CAS  Google Scholar 

  24. Huddleston, J.G., Visser, A.E., Reichert, W.M., Willauer, H.D., Broker, G.A., Rogers, R.D.: Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation. Green Chem. 3, 156–164 (2001)

    Article  CAS  Google Scholar 

  25. Pal, A., Yadav, A.: Interactions between surface active ionic liquid and procaine hydrochloride drug in aqueous solution. J. Solution Chem. 47, 1096–1111 (2018)

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The financial support from Arak University Research Council is gratefully acknowledged (Grant No. 97–37).

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Arak University, 38156-8-8349, Arak, Iran

    Elham Parsi & Alireza Salabat

  2. Institue of Nanosciences & Nanotechnolgy, Arak University, 38156-8-8349, Arak, Iran

    Alireza Salabat

Authors
  1. Elham Parsi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alireza Salabat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alireza Salabat.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parsi, E., Salabat, A. Comparison of O/W and IL/W Microemulsion Systems as Potential Carriers of Sparingly Soluble Celecoxib Drug. J Solution Chem 49, 68–82 (2020). https://doi.org/10.1007/s10953-019-00940-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10953-019-00940-9

Keywords

Search

Navigation