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Ionic Liquid Assisted Microemulsions for Drug Delivery

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Application of Ionic Liquids in Drug Delivery

Abstract

In this chapter after the definition of traditional microemulsions, a new type of microemulsion system, namely, ionic liquid based microemulsion, has been introduced. Ionic liquids comprising microemulsions may be acting as polar or non-polar phases as well as surfactant agent. Then, three types of ionic liquid based microemulsions will be formed as non-aqueous IL microemulsions, aqueous IL microemulsions, and IL/oil/water microemulsions. It has been discussed that the ionic liquid based microemulsions are able to overcome the inabilities of conventional microemulsions to dissolve a number of chemicals which are water insoluble and result in better pharmacological activities of drugs. Most importantly, in the drug delivery field, ionic liquid based microemulsions can serve better bioavailability, permeation, and stability. Additionally, one of the most important applications of ionic liquid based microemulsions, as drug nanocarrier, has been discussed in details. The mechanism of solubility enhancement of an active pharmaceutical ingredient and transdermal drug delivery by using ionic liquid based microemulsion is highlighted. It is also discussed that hydrophobic nontoxic ionic liquids can be used to prepare novel ionic liquid based microemulsions for intravenous administration.

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Abbreviations

IL:

Ionic liquid

RTIL:

Room temperature ionic liquid

SAIL:

Surface active ionic liquid

ME:

Microemulsion

MEG:

Microemulgel

SFME:

Surfactant free microemulsion

O/W:

Oil-in-water

W/O:

Water-in-oil

IL/W:

Ionic liquid-in-water

W/IL:

Water-in-ionic liquid

IL/O:

Ionic liquid-in-oil

O/IL:

Oil-in-ionic liquid

BC:

Bicontinuous phase

DLS:

Dynamic light scattering

API:

Active pharmaceutical ingredient

TDD:

Transdermal drug delivery

UV-vis:

UV–vis spectroscopy

TEM:

Transmission electron microscopy

AFM:

Atomic force microscopy

TEWL:

Trans-epidermal water loss values

ATR-FTIR:

Attenuated total Reflectance Fourier Transform Infrared

MMA:

Methyl methacrylate

AOT:

Sodium bis(2-ethylhexyl)sulfosuccinate

IPM:

Isopropyl myristate

ACV:

Acyclovir

MTX:

Methotrexate

Den:

Dencichine

Ars:

Artemisinin

SC:

Stratum corneum

Ch:

Cholinium

CA:

Carboxylic acids

[C2mim][BF4]:

1-ethyl-3-methylimidazolium tetrauoroborate

[C4mim][BF4]:

1-butyl-3-methylimidazolium tetrauoroborate

[C8mim][BF4]:

1-octyl-3-methylimidazolium tetrauoroborate

[C4mim][PF6]:

1-butyl-3-methylimidazolium hexauorophosphate

[C8mim][NTf2]:

1-octyl-3-methylimidazolium bis(triuoromethylsulfonyl)imide

[Ch][Ole]:

Choline oleate

[Ch][Lin]:

Choline linoleate

[Ch][Eru]:

Choline erucate

[Ch][For]:

Choline formate

[Ch][Lac]:

Choline lactate

[Ch][Pro]:

Choline propionate

[C1mim][(CH3O)2PO2]:

Dimethylimidazolium dimethylphosphate

[HOEmim][Cl]:

1-hydroxyethyl-3-methylimidazolium chloride

[C4mim][C12SO3:

1-butyl-3-methylimidazolium dodecanesulfate

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Arak University, 38156-8-8349, Arak, Iran

    Alireza Salabat

  2. Institute of Nanosciences and Nanotechnology, Arak University, 38156-8-8349, Arak, Iran

    Alireza Salabat

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  1. Alireza Salabat
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Correspondence to Alireza Salabat .

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Editors and Affiliations

  1. Department of Applied Chemistry, Kyushu University, Fukuoka, Japan

    Masahiro Goto

  2. Department of Chemical Engineering, Universiti Teknologi PETRONAS, Perak, Malaysia

    Muhammad Moniruzzaman

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Salabat, A. (2021). Ionic Liquid Assisted Microemulsions for Drug Delivery. In: Goto, M., Moniruzzaman, M. (eds) Application of Ionic Liquids in Drug Delivery. Springer, Singapore. https://doi.org/10.1007/978-981-16-4365-1_12

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