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Antibacterial and Antibiofilm Potential of Mono-dispersed Stable Copper Oxide Nanoparticles-Streptomycin Nano-drug: Implications for Some Potato Plant Bacterial Pathogen Treatment

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Abstract

The novelty of this work is to estimate the antibacterial and antibiofilm capabilities of the mono-dispersed copper oxide nanoparticles (CuO NPs)-streptomycin nano-drug which synthesized by a cost-effective and eco-friendly gamma irradiation method. The incorporated CuO NPs-streptomycin was fully defined by UV–Vis., XRD, FTIR, HRTEM, DLS, HRSEM and EDX elemental analysis. In vitro antibacterial and antibiofilm activities of CuO NPs-streptomycin were examined towards pathogenic bacteria-causing brown, ring, soft rot and black leg diseases in potato plant. The proposed reaction mechanism regarding the synergistic potential between CuO NPs and streptomycin was estimated. The incorporated CuO NPs-streptomycin displayed an absorption peak at 585.0 nm specific for the Surface Plasmon Resonance. Results achieved from HRTEM, HRSEM and XRD verified the mono-dispersed crystalline character of the fabricated CuO NPs-streptomycin with a common particle size of 20.20 nm. CuO NPs-streptomycin exhibited an encouraging antibacterial activity against Clavibacter michiganensis subsp. sepedonicus (35.50 mm ZOI). Additionally, CuO NPs-streptomycin displayed enhanced biofilm inhibition percentage of about 90.99%, 84.23%, and 83.42% toward C. michiganensis subsp. sepedonicus, Ralstonia solanacearum, and Dickeya solani, respectively. Consequently, according to the prominent characteristics, this research could provide insights for determining dangerous agricultural challenges, potato packaging and processing and new nano-drug formula for invading potato pathogenic bacteria through the cultivation.

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Acknowledgements

The authors would like to thank the Nanotechnology Research Unit (P.I. Prof. Dr. Ahmed I. El-Batal), Drug Microbiology Lab., Drug Radiation Research Department, NCRRT, Egypt, for financing and supporting this study under the project “Nutraceuticals and Functional Foods Production by using Nano/Biotechnological and Irradiation Processes”. Also, the authors would like to thank Prof. Mohamed Gobara (Military Technical College, Egyptian Armed Forces), and Zeiss microscope team in Cairo for their invaluable advice during this study.

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Authors and Affiliations

  1. Drug Radiation Research Department, Biotechnology Division, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

    Ahmed I. El-Batal & Gharieb S. El-Sayyad

  2. Bacterial Disease Research Department, Plant Pathology Research Institute, Agricultural Research Center (ARC), Giza, Egypt

    Naglaa M. Balabel

  3. Potato Brown Rot Project, Ministry of Agriculture, Dokki, Giza, Egypt

    Naglaa M. Balabel

  4. Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

    Mohamed S. Attia

  5. Chemical Engineering Department, Military Technical College, Egyptian Armed Forces, Cairo, Egypt

    Gharieb S. El-Sayyad

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  2. Naglaa M. Balabel
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  3. Mohamed S. Attia
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  4. Gharieb S. El-Sayyad
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Correspondence to Gharieb S. El-Sayyad.

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El-Batal, A.I., Balabel, N.M., Attia, M.S. et al. Antibacterial and Antibiofilm Potential of Mono-dispersed Stable Copper Oxide Nanoparticles-Streptomycin Nano-drug: Implications for Some Potato Plant Bacterial Pathogen Treatment. J Clust Sci 31, 1021–1040 (2020). https://doi.org/10.1007/s10876-019-01707-4

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