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One-Pot Synthesis of Dysprosium Oxide Nano-Sheets: Antimicrobial Potential and Cyotoxicity on A549 Lung Cancer Cells

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Abstract

The present work deals with green synthesis of dysprosium oxide nano-sheets (Dy2O3 NS) using Syzygium travancoricum leaf extract. Synthesized NS were characterized by UV–VIS–DRS, ATR-FT-IR, PL, Raman spectroscopy, XRD, TEM with EDX and XPS analysis. UV–VIS–DRS analysis showed the absorption peak at 355 nm and band gap value of 4.8 eV. ATR-FT-IR analysis was performed to analyze the biomolecules responsible for formation of Dy2O3 NS. Micro-Raman analysis showed a peak at 373 cm−1. XRD confirmed the presence of Dy2O3 NS with body-centered cubic structure. TEM images revealed the presence of nano sheets with size ranging from 100 to 200 nm and EDX analysis showed Dy and O elements and no other elements were detected, which indicates the purity of the resultant Dy2O3 NS. The synthesized Dy2O3 NS were tested against different bacterial and fungal species as well as cytotoxic agents on A549 lung cancer cells. The antimicrobial activity of Dy2O3 NS was significant on all the tested species. Cytotoxicity of Dy2O3 NS was revealed against A549 lung cancer cell lines in a dose-dependent manner. The results suggest that the synthesized Dy2O3 NS may be a promising candidate in the field of biomedical applications.

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Acknowledgements

The authors extend their sincere appreciations to the Deanship of Scientific Research at King Saud University for its funding this Prolific Research Group (PRG-1437-36). G. Benelli is sponsored by PROAPI (PRAF 2015) and University of Pisa, Department of Agriculture, Food and Environment (Grant ID: COFIN2015_22). Funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. One of the authors K. Gopinath is highly grateful to thank Mr. C. Karthikeyan, Jamal Mohamed College, Trichy, Tamil Nadu, India, for helping to analyze the XRD and XPS results with standard fitting. We sincerely thank the KRIND Institute of Research and Development, Trichy, for helping in antimicrobial activity assays.

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Authors and Affiliations

  1. Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, 641 046, India

    Kasi Gopinath & Natarajan Parimala Devi

  2. Department of Nanoscience and Technology, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    Mari Chinnadurai & Tamilvanan Baranisri

  3. EMFT Division, CSIR- Central Electrochemical Research Institute, Karaikudi, Tamil Nadu, 630 003, India

    Kasi Bhakyaraj & Shanmugasundaram Kumaraguru

  4. Department of Bioinformatics, Alagappa University, Karaikudi, 630 003, India

    Arumugam Sudha

  5. Mahatma Gandhi-Doerenkamp Center, Bharathidasan University, Tiruchirappalli, 620 024, India

    Mohammed Zeeshan

  6. Department of Botany, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India

    Ayyakannu Arumugam

  7. Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India

    Marimuthu Govindarajan

  8. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Naiyf S. Alharbi & Shine Kadaikunnan

  9. Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy

    Giovanni Benelli

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  1. Kasi Gopinath
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  2. Mari Chinnadurai
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  3. Natarajan Parimala Devi
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  5. Shanmugasundaram Kumaraguru
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  6. Tamilvanan Baranisri
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  8. Mohammed Zeeshan
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  9. Ayyakannu Arumugam
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  11. Naiyf S. Alharbi
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  12. Shine Kadaikunnan
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  13. Giovanni Benelli
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Correspondence to Kasi Gopinath.

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Gopinath, K., Chinnadurai, M., Devi, N.P. et al. One-Pot Synthesis of Dysprosium Oxide Nano-Sheets: Antimicrobial Potential and Cyotoxicity on A549 Lung Cancer Cells. J Clust Sci 28, 621–635 (2017). https://doi.org/10.1007/s10876-016-1150-4

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  • DOI: https://doi.org/10.1007/s10876-016-1150-4

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