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Colorimetric chemosensor based on a carminic acid and Pb2+ complex for selective detection of cysteine over homocysteine and glutathione in aqueous solution

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Abstract

We have developed a colorimetric chemosensor for the selective and sensitive detection of Cys based on the complex (CA-2Pb2+) between a commercially available natural organic dye, carminic acid (CA) and Pb2+ in pure aqueous solution at physiological pH. The addition of Cys to the CA-2Pb2+ solution resulted in a distinct color change from purple to red together with a remarkable absorption spectral change by the restoration of CA through a displacement mechanism with formation of the Cys-Pb2+ complex, whereas other amino acids and glutathione induce no or minimal spectral and color changes. Moreover, the other amino acids and GSH do not affect the detection ability of CA-2Pb2+ for Cys. The reversibility even through several cycles was established for practical applications. The results indicate that CA-2Pb2+ may be useful as a potential colorimetric and naked-eye chemosensor for Cys over Hcy and GSH in aqueous solution.

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Authors and Affiliations

  1. Faculty of Science and Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama, 350-8585, Japan

    Koshiro Inoue & Yasumasa Fukushima

  2. Research Institute of Industrial Technology, Toyo University, 2100 Kujirai, Kawagoe, Saitama, 350-8585, Japan

    Shunichi Aikawa

Authors
  1. Koshiro Inoue
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  2. Shunichi Aikawa
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  3. Yasumasa Fukushima
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Correspondence to Yasumasa Fukushima.

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Inoue, K., Aikawa, S. & Fukushima, Y. Colorimetric chemosensor based on a carminic acid and Pb2+ complex for selective detection of cysteine over homocysteine and glutathione in aqueous solution. J Incl Phenom Macrocycl Chem 90, 105–110 (2018). https://doi.org/10.1007/s10847-017-0772-y

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