Abstract
Plants of the genus Psidium have been employed in “in natura” consumption and agroindustry, and owing to the diversity of phytochemicals, the development of new pharmaceutical forms has received remarkable research interest. In this study, the essential oil obtained from Psidium glaziovianum (PgEO) leaves were evaluated antinociceptive and anti-inflammatory activities were evaluated in mouse models. Initially, PgEO was characterized by gas chromatography–mass spectrometry and gas chromatography with flame ionization detection, and the profile was dominated by sesquiterpene compounds. In the evaluation of acute antinociceptive activity (abdominal contortions induced by acetic acid, formalin, tail immersion, and hot plate tests), PgEO promoted a reduction in nociception in the chemical and thermal models. Additionally, the potential underlying mechanism was investigated using pain pathway blockers, and the results revealed a combined action of opioidergic and muscarinic pathways. The anti-inflammatory potential was confirmed by anti-edematogenic action, reduced cell migration, pro-inflammatory cytokine production, and granuloma formation in chronic processes. This study provides evidence that PgEO can be effective for the treatment of pain and acute and chronic inflammation.
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Acknowledgements
The authors express their gratitude to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Finance Code 001) and to the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for research grants (DMAFN, THN, MTSC). WKC and MFN would like to thank CNPq for graduate scholarship. AMO would like to thank FACEPE (BFP-0122-4.03/19) for the post-doctoral scholarship. We thank the Paus dóia community for their welcome in collecting botanical material.
Funding
Fuding was provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Finance Code 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE).
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Costa, W.K., do Nascimento, M.F., dos Santos, C.R.B. et al. Oral administration of essential oil from Psidium glaziovianum Kiaersk leaves alleviates pain and inflammation in mice. Inflammopharmacol 30, 599–607 (2022). https://doi.org/10.1007/s10787-022-00940-0
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DOI: https://doi.org/10.1007/s10787-022-00940-0