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Two New Anti-Tobacco Mosaic Virus Quinolin-2(1H)-Ones from the Twigs of Cassia auriculata

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Chemistry of Natural Compounds Aims and scope

Two new quinolin-2(1H)-ones, 7-methoxy-6-methyl-4-(4-methylfuran-2-yl)quinolin-2(1H)-one (1) and 7-hydroxy-6-methyl-4-(4-methylfuran-2-yl)quinolin-2(1H)-one (2), were isolated from the twigs of Cassia auriculata. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited potential anti-TMV activity with inhibition rates of 38.4 and 49.2%, respectively.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 21762050), the Foundation of Yunnan Innovative Research Team, the Yunnan Applied Basic Research Projects for Excellent Young Scholars (Grant to M. Z.), and Yunnan Innovative Research Team for Discovery and Comprehensive Utilization of Functional Small Molecules in Medicinal Plants (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, 650031, Kunming, P. R. China

    Chao-Pei Zheng, Ling-Fang Zhang, Yin-Ke Li, Qiu-Fen Hu, Zhou Min & Yan-Qing Ye

  2. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd, 650231, Kunming, P. R. China

    Chao-Pei Zheng, Wen Xiong, Wang Jin, Jian-Duo Zhang, Yin-Ke Li & Qiu-Fen Hu

  3. Yunnan Academy of Tobacco Agricultural Sciences, 650031, Kunming, P. R. China

    Guang-Hui Kong & Yu-Ping Wu

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  1. Chao-Pei Zheng
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  2. Wen Xiong
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  3. Ling-Fang Zhang
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  4. Wang Jin
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  5. Jian-Duo Zhang
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  6. Yin-Ke Li
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  7. Qiu-Fen Hu
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  8. Zhou Min
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  9. Guang-Hui Kong
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  10. Yan-Qing Ye
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Corresponding authors

Correspondence to Yan-Qing Ye or Yu-Ping Wu.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023 pp. 95–97

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Zheng, CP., Xiong, W., Zhang, LF. et al. Two New Anti-Tobacco Mosaic Virus Quinolin-2(1H)-Ones from the Twigs of Cassia auriculata. Chem Nat Compd 59, 107–110 (2023). https://doi.org/10.1007/s10600-023-03928-6

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  • DOI: https://doi.org/10.1007/s10600-023-03928-6

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