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Two New Anti-Tobacco Mosaic Virus Quinoline Alkaloids from the Stems of Nicotiana tabacum

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Chemistry of Natural Compounds Aims and scope

Two new quinoline alkaloids, 4-acetyl-7-isopropyl-6-methylquinolin-2(1H)-one (1) and 4-acetyl-7-isopropyl-5-methylquinolin-2(1H)-one (2), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 38.5 and 42.2% at the concentration of 20 μM, respectively. These rates are higher than that of positive control.

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Acknowledgment

This work was supported financially by the Foundation of Yunnan basic research program (2019FD086), the National Natural Science Foundation of China (No. 21967021), the Foundation of Yunnan Tobacco Industry Co., Ltd. (2018JC07), and the high-tech Projects of Yunnan Province (2017ZE027).

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Authors and Affiliations

  1. Technology Center, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Le-Le Deng, Wen-Wu Yang, Jia-Rui Jiang, Li Xu, Jian-Duo Zhang, Chun-Bo Liu, Jun Ling, Wei-Song Kong, Xue-Mei Li, Yin-Ke Li, Xin Liu & Tao Zhou

  2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Le-Le Deng & Tao Zhou

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  1. Le-Le Deng
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  2. Wen-Wu Yang
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  4. Li Xu
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  11. Xin Liu
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Correspondence to Xin Liu or Tao Zhou.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2022, pp. 72–74.

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Deng, LL., Yang, WW., Jiang, JR. et al. Two New Anti-Tobacco Mosaic Virus Quinoline Alkaloids from the Stems of Nicotiana tabacum. Chem Nat Compd 58, 78–81 (2022). https://doi.org/10.1007/s10600-022-03600-5

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  • DOI: https://doi.org/10.1007/s10600-022-03600-5

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