Two new isoindolin-1-ones, 6-(3-hydroxypropyl)-2,4-dimethylisoindolin-1-one (1) and 4-(hydroxymethyl)-6-(3-hydroxypropyl)-2-methylisoindolin-1-one (2), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activities with inhibition rates of 42.3 and 46.2% at the concentration of 20 μM, respectively.
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Acknowledgment
This work was supported financially by the Foundation of Yunnan Basic Research Program (2019FD086), the National
Natural Science Foundation of China (No. 21967021), the Foundation of Yunnan Tobacco Industry Co., Ltd. (2018JC07),
and the high-tech Projects of Yunnan Province (2017ZE027).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2021, pp. 898–900.
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Xu, L., Zhou, T., Zhang, JD. et al. Two New Anti-Tobacco Mosaic Virus Isoindolin-1-Ones from the Leaves of Nicotiana tabacum. Chem Nat Compd 57, 1047–1050 (2021). https://doi.org/10.1007/s10600-021-03547-z
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DOI: https://doi.org/10.1007/s10600-021-03547-z