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Physiologic implications of metal-ion transport by ZIP14 and ZIP8

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Abstract

Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural components of larger molecules that are indispensable for life. The three metal ions possess similar chemical properties and have been shown to compete for uptake in a variety of tissues, suggesting that they share common transport proteins. Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium. Although knockout and transgenic mouse models are beginning to define the physiologic roles of ZIP14 and ZIP8 in the handling of zinc and cadmium, their roles in the metabolism of iron and manganese remain to be defined. Here we review similarities and differences in ZIP14 and ZIP8 in terms of structure, metal transport, tissue distribution, subcellular localization, and regulation. We also discuss potential roles of these proteins in the metabolism of zinc, iron, manganese, and cadmium as well as recent associations with human diseases.

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Acknowledgment

Supported by National Institutes of Health Grant R01 DK080706 and R01 DK080047.

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Authors and Affiliations

  1. Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, 32611, USA

    Supak Jenkitkasemwong, Chia-Yu Wang & Mitchell D. Knutson

  2. Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA

    Bryan Mackenzie

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  1. Supak Jenkitkasemwong
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  2. Chia-Yu Wang
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  3. Bryan Mackenzie
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  4. Mitchell D. Knutson
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Correspondence to Mitchell D. Knutson.

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Jenkitkasemwong, S., Wang, CY., Mackenzie, B. et al. Physiologic implications of metal-ion transport by ZIP14 and ZIP8. Biometals 25, 643–655 (2012). https://doi.org/10.1007/s10534-012-9526-x

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