Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 2003;112(12):1776-1784.
Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009;119(6):1420-1428.
Meneghin A, Hogaboam CM. Infectious disease, the innate immune response, and fibrosis. J. Clin. Invest. 2007;117(3):530-538.
Nguyen-Van-Tam JS, Openshaw PJ, Hashim A, Gadd EM, Lim WS, Semple MG, Read RC, Taylor BL, Brett SJ, McMenamin J, Enstone JE, Armstrong C, Nicholson KG; Influenza Clinical Information Network (FLU-CIN). Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax. 2010;65(7):645-651.
Potapova OV, Kovner AV, Anikina AG, Cherdantseva LA, Sharkova TV, Shkurupy VA, Vasil’eva EV, Shestopalov AM. Studies of influenza A/H1N1 A/Tomsk/13/2010 virus topology during development of infectious process in mammals. Bull. Exp. Biol. Med. 2016;160(5):683-686.
Spagnolo P, Rossi G, Cavazza A. Pathogenesis of idiopathic pulmonary fibrosis and its clinical implications. Expert Rev. Clin. Immunol. 2014;10(8):1005-1017.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 598-601, November, 2016
Rights and permissions
About this article
Cite this article
Shatskaya, E.V., Kovner, A.V., Potapova, O.V. et al. Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus. Bull Exp Biol Med 162, 647–649 (2017). https://doi.org/10.1007/s10517-017-3678-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3678-1