The effects of 30-min medium-intensity exercise on the expression of genes encoding heat shock protein 70 (HSPA1A) and its cochaperones HSP-70-binding protein 1 (HSPBP1) and Tag7 (PGLYRP1) in human leukocytes were studied. Transcription activities of HSPA1A and PGLYRP1 genes increased immediately after medium-intensity exercise, while activity of HSPBP1 gene remained unchanged. During recovery after exercise, the expression of HSPA1A gene virtually did not change, while the expression of PGLYRP1 gene continued to increase and after 90 min more than 2-fold surpassed the basal level.
Similar content being viewed by others
References
A. I. Grigoryev and A. G. Tonevitsky, Ros. Fiziol. Zh., 95, No. 10, 1041-1057 (2009).
A. E. Donnikov, M. U. Shkurnikov, E. B. Akimov, and A. G. Tonevitsky, Bull. Exp. Biol. Med., 146, No. 4, 462-465 (2008).
E. A. Dukhanina, D. V. Yashin, A. V. Galkin, and L. P. Sashchenko, Cell Cycle, 9, No. 4, 676-682 (2010).
E. S. Grebenyuk, T. V. Stupnikova, D. A. Sakharov, et al., Bull. Exp. Biol. Med., 149, No. 5, 640-644 (2010).
R. A. Irizarry, B. Hobbs, F. Collin, et al., Biostatistics, 4, No. 2, 249-264 (2003).
D. V. Maltseva, D. A. Sakharov, A. G. Tonevitsky, et al., Exerc. Immunol. Rev., 17, 150-163 (2011).
D. A. Raynes and V. Guerriero Jr., J. Biol. Chem., 273, No. 49, 32 883-32 888 (1998).
E. A. Riabenko, E. A. Tonevitsky, A. G. Tonevitsky, et al., Am. J. Biomed. Sc., 3, No. 2, 90-94 (2011).
D. A. Sakharov, D. V. Maltseva, E. A. Riabenko, et al., Eur. J. Appl. Physiol., 112, No. 3, 963-972 (2011).
D. A. Sakharov, A. V. Stepanov, M. Y. Shkurnikov, A. G. Tonevitsky, Bull. Exp. Biol. Med., 147, No. 3, 361-365 (2009).
M. Y. Shkurnikov, A. E. Donnikov, E. B. Akimov, et al., Bull. Exp. Biol. Med., 146, No. 3, 354-357 (2008).
V. A. Sleptsova, E. S. Grebenyuk, S. A. Khaustova, Ibid., 149, No. 6, 755-758 (2010).
D. V. Yashin, E. A. Dukhanina, O. D. Kabanova, et al., Biochimie, 94, No. 1, 203-206 (2012).
D. V. Yashin, E. A. Dukhanina, O. D. Kabanova, et al., J. Biol. Chem., 286, No. 12, 10 258-10 264 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 6, pp. 846-849, June, 2012
Rights and permissions
About this article
Cite this article
Maltseva, D.V., Ryabenko, E.A., Sizova, S.V. et al. Effect of Exercise on the Expression of HSPBP1, PGLYRP1, and HSPA1A Genes in Human Leukocytes. Bull Exp Biol Med 153, 867–869 (2012). https://doi.org/10.1007/s10517-012-1846-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1846-x