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Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis and the plasmatic and salivary levels of RANKL and Survivin: a short-term clinical study

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Abstract

Aim

To investigate the influence of nonsurgical periodontal treatment (NSPT) on clinical periodontal status, rheumatoid arthritis (RA) activity, and plasmatic and salivary levels of biomarkers through a controlled clinical trial on individuals with RA and periodontitis (PE).

Methods

Sixty-six individuals from a convenience sample were considered eligible and consecutively allocated in 3 groups: (1) individuals without PE and RA (-PE-RA, n = 19); (2) individuals without PE and with RA (-PE+RA, n = 23), and (3) individuals with PE and RA (+PE+RA, n = 24). Full-mouth periodontal clinical examinations, Disease Activity Score (DAS-28) evaluations, and analysis in plasma and saliva of RANKL, OPG, RANKL/OPG, and Survivin were performed at baseline (T1) and 45 days after NSPT (T2).

Results

NSPT in the +PE+RA group was very effective to improve periodontal condition. At T2, significant reductions in DAS-28 were observed in +PE+RA (p = 0.011). Significantly higher levels of Survivin and RANKL were observed in saliva and plasma from RA individuals (with and without PE) compared to controls. Additionally, Survivin e RANKL demonstrated positive correlations with DAS-28 and an expressively significant reduction in +PE+RA at T2 (p < 0.001).

Conclusions

NSPT was effective on improving both the periodontal and the RA clinical status and reducing the concentration of Survivin and RANKL in saliva and plasma.

Practical implications

Nonsurgical periodontal treatment was effective on reducing the concentration of Survivin and RANKL and on improving both the periodontal and the RA clinical status of affected individuals.

Trial registration

Brazilian Registry of Clinical Trials (ReBEC) protocol #RBR-8g2bc8 (http://www.ensaiosclinicos.gov.br/rg/RBR-8g2bc8/).

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Funding

This study was supported by grants from the National Council of Scientific and Technological Development – CNPq, Brasília, Brazil (Productivity research grant #402158/2016-4).

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Authors and Affiliations

  1. Department of Dental Clinics, Oral Pathology, and Oral Surgery, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Marcela Faria Moura, Tarcília Aparecida Silva, Luís Otávio Miranda Cota, Sicilia Rezende Oliveira & Fernando Oliveira Costa

  2. School of Dentistry, University of Ribeirão Preto, São Paulo, Brazil

    Fernando Queiroz Cunha

  3. School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Gilda Aparecida Ferreira

  4. Departament of Dentistry, Periodontics Research Division, University of Taubaté, São Paulo, Brazil

    José Roberto Cortelli & Sheila Cavalca Cortelli

  5. Faculty of Dentistry, Department of Periodontology, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Pampulha, PO Box 359, Belo Horizonte, Minas Gerais, Zip Code 31270-901, Brazil

    Fernando Oliveira Costa

Authors
  1. Marcela Faria Moura
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  2. Tarcília Aparecida Silva
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  3. Luís Otávio Miranda Cota
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  4. Sicilia Rezende Oliveira
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  5. Fernando Queiroz Cunha
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  6. Gilda Aparecida Ferreira
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  7. José Roberto Cortelli
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  8. Sheila Cavalca Cortelli
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  9. Fernando Oliveira Costa
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Contributions

All authors have made substantial contributions to the conception and design of the study. MFM, TAS, SRO, FQC, JRC, and FOC have been involved in data collection and data analysis. MFM, TAS, SRO, FQC, GAF, LOMC, SCC, JRC, and FOC have been involved in data interpretation, drafting the manuscript and critically revising it, having given their final approval on the version to be published.

Corresponding author

Correspondence to Fernando Oliveira Costa.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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The authors declare no competing interests.

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Informed consent was obtained from all individual participants included in the study.

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Moura, M.F., Silva, T.A., Cota, L.O.M. et al. Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis and the plasmatic and salivary levels of RANKL and Survivin: a short-term clinical study. Clin Oral Invest 25, 6643–6652 (2021). https://doi.org/10.1007/s00784-021-03950-4

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