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Beyond energy minimization: approaches to the kinetic folding of RNA

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Abstract

The term RNA folding is often used synonymously with the prediction of equilibrium structures. Yet many RNAs function thanks to their ability to undergo structural changes. In this contribution we present a systematic overview of existing approaches to the prediction of RNA folding kinetics, and in particular discuss the strengths and limitations of each method.

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  1. Institute of Theoretical Chemistry, University of Vienna, Wien, Austria

    Christoph Flamm & Ivo L. Hofacker

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  1. Christoph Flamm
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  2. Ivo L. Hofacker
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Correspondence to Ivo L. Hofacker.

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Correspondence: Ivo L. Hofacker, Institute of Theoretical Chemistry, University of Vienna, Währingerstraße 17, 1090 Wien, Austria.

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Flamm, C., Hofacker, I. Beyond energy minimization: approaches to the kinetic folding of RNA . Monatsh Chem 139, 447–457 (2008). https://doi.org/10.1007/s00706-008-0895-3

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