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On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors

  • Basic Neurosciences, Genetics and Immunology - Original Article
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Abstract

Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may ‘guide-and-clasp’ receptor–receptor interactions.

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Authors and Affiliations

  1. St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia

    Alexander O. Tarakanov

  2. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden

    Kjell G. Fuxe & Dasiel O. Borroto-Escuela

Authors
  1. Alexander O. Tarakanov
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  2. Kjell G. Fuxe
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  3. Dasiel O. Borroto-Escuela
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Correspondence to Alexander O. Tarakanov.

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Tarakanov, A.O., Fuxe, K.G. & Borroto-Escuela, D.O. On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors. J Neural Transm 119, 517–523 (2012). https://doi.org/10.1007/s00702-011-0734-2

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  • DOI: https://doi.org/10.1007/s00702-011-0734-2

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