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3-Dimensional hollow graphene balls for voltammetric sensing of levodopa in the presence of uric acid

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Abstract

The development of novel nanomaterials brings new opportunity and challenge for high sensing detection of biomolecules. The authors describe the preparation of 3-dimentional hollow graphene balls (3D HGBs) using nickel nanoparticles (Ni-NPs) as the template. The Ni-NPs were synthesized by chemical reduction of nickel chloride and then graphene was coated onto their surface via carburization and carbonization. After etching Ni-NPs, 3D HGBs with few layers and a typical size of 100 nm were obtained. They were sprayed onto indium tin oxide glass to obtain a working electrode for electrochemical determination of levodopa in the presence of uric acid. Due to the unique hollow porous structure of the 3D HGBs, the electrode exhibits a sensitivity of 0.69 μA·μM−1·cm−2 and a 1 μM limit of detection. It is selective, reproducible and stable. It was applied to the determination of levodopa in spiked human plasma samples and it is of potential use in clinical research.

Schematic presentation of the preparation of 3-dimensional hollow graphene balls (HGBs) by using nickel nanoparticles as a template that can be removed by etching. The HGBs were sprayed onto indium tin oxide (ITO) glass to obtain a working electrode that has a sensitivity of 0.69 μA⋅μM−1·cm−2 and a 1 μM limit of detection for the determination of levodopa.

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References

  1. Shannon KM (2008) Long-term outcome in Parkinson disease: no advantage to initiating therapy with dopamine agonists. Nat Clin Pract Neurol 4:590–591

    Article  CAS  Google Scholar 

  2. Dashtipour K, Johnson E, Kani C, Kani K, Hadi E, Ghamsary M, Pezeshkian S, Chen JJ (2015) Effect of exercise on motor and nonmotor symptoms of Parkinson's disease. Parkinsons Dis. https://doi.org/10.1155/2015/586378

  3. Schapira AH, Emre M, Jenner P, Poewe W (2009) Levodopa in the treatment of Parkinson’s disease. Eur J Neurol 16:982–989

  4. Rascol O, Goetz C, Koller W, Poewe W, Sampaio C (2002) Treatment interventions for Parkinson’s disease: an evidence based assessment. Lancet 359:1589–1598

  5. Stocchi F, Tagliati M, Olanow CW (2008) Treatment of levodopa-induced motor complications. Movement Disord 23:S599–S612

    Article  Google Scholar 

  6. Karimi M, Carl JL, Loftin S, Perlmutter JS (2006) Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid. J Chromatogr B 836:120–123

    Article  CAS  Google Scholar 

  7. Grunhut M, Garrido M, Centurion ME, Fernandez Band BS (2010) Kinetic approach for the enzymatic determination of levodopa and carbidopa assisted by multivariate curve resolution-alternating least squares. Anal Chim Acta 673:33–39

    Article  Google Scholar 

  8. Lai PJ, Harroun SG, Chen SY, Unnikrishnan B, Li YJ, Huang CC (2016) Solid-state synthesis of self-functional carbon quantum dots for detection of bacteria and tumor cells. Sensor Actuat B-Chem 228:465–470

    Article  CAS  Google Scholar 

  9. Zhang Y, Gao SY (2014) Determination of picogram levels of levodopa in pharmaceutical preparations and biofluids by flow-injection chemiluminescence. Adv Mater Res 884:566–569

    Article  Google Scholar 

  10. Li H, Wang Y, Ye D, Luo J, Su B, Zhang S, Kong J (2014) An electrochemical sensor for simultaneous determination of ascorbic acid, dopamine, uric acid and tryptophan based on MWNTs bridged mesocellular graphene foam nanocomposite. Talanta 127:255–261

    Article  CAS  Google Scholar 

  11. Manjunatha R, Suresh GS, Melo JS, Venkatesha TV (2010) Simultaneous determination of ascorbic acid, dopamine and uric acid using polystyrene sulfonate wrapped multiwalled carbon nanotubes bound to graphite electrode through layer-by-layer technique. Sensor Actuat B-Chem 145:643–650

    Article  CAS  Google Scholar 

  12. Wang J, Yang B, Li S, Yan B, Xu H, Zhang K, Shi Y, Zhai C, Du Y (2017) Enhanced photo-electrochemical response of reduced graphene oxide and C3N4 nanosheets for rutin detection. J Colloid Interf Sci 506:329–337

    Article  CAS  Google Scholar 

  13. Wang J, Yang B, Zhong J, Yan B, Zhang K, Zhai C, Shiraishi Y, Du Y, Yang P (2017) Dopamine and uric acid electrochemical sensor based on a glassy carbon electrode modified with cubic Pd and reduced graphene oxide nanocomposite. J Colloid Interf Sci 497:172–180

    Article  CAS  Google Scholar 

  14. Li S, Zhang K, Wang J, Yan B, Wang C, Xiong Z, Xu H, Du Y (2017) Enhanced TA determination on 3D flower-like ZnO-Pt nanocomposites under ultraviolet light illumination. Sensor Actuat B-Chem 252:717–724

    Article  CAS  Google Scholar 

  15. Zou C, Yang B, Bin D, Wang J, Li S, Yang P, Wang C, Shiraishi Y, Du Y (2017) Electrochemical synthesis of gold nanoparticles decorated flower-like graphene for high sensitivity detection of nitrite. J Colloid Interf Sci 488:135–141

    Article  CAS  Google Scholar 

  16. Hosseini MG, Faraji M, Momeni MM, Ershad S (2011) An innovative electrochemical approach for voltammetric determination of levodopa using gold nanoparticles doped on titanium dioxide nanotubes. Microchim Acta 172:103–108

    Article  CAS  Google Scholar 

  17. Movlaee K, Beitollahi H, Ganjali MR, Norouzi P (2017) Electrochemical platform for simultaneous determination of levodopa, acetaminophen and tyrosine using a graphene and ferrocene modified carbon paste electrode. Microchim Acta 184:3281–3289

    Article  CAS  Google Scholar 

  18. Mazloum-Ardakani M, Taleat Z, Khoshroo A, Beitollahi H, Dehghani H (2012) Electrocatalytic oxidation and voltammetric determination of levodopa in the presence of carbidopa at the surface of a nanostructure based electrochemical sensor. Biosens Bioelectron 35:75–81

    Article  CAS  Google Scholar 

  19. Kul D, Brett CMA (2014) Electrochemical investigation and determination of levodopa on poly(nile blue-A)/multiwalled carbon nanotube modified glassy carbon electrodes. Electroanalysis 26:1320–1325

    Article  CAS  Google Scholar 

  20. Babaei A, Sohrabi M, Taheri AR (2013) Highly sensitive simultaneous determination of l-dopa and paracetamol using a glassy carbon electrode modified with a composite of nickel hydroxide nanoparticles/multi-walled carbon nanotubes. J Electroanal Chem 698:45–51

    Article  CAS  Google Scholar 

  21. Rezaei B, Shams-Ghahfarokhi L, Havakeshian E, Ensafi AA (2016) An electrochemical biosensor based on nanoporous stainless steel modified by gold and palladium nanoparticles for simultaneous determination of levodopa and uric acid. Talanta 158:42–50

    Article  CAS  Google Scholar 

  22. Huang Y, Dong X, Liu Y, Li LJ, Chen P (2011) Graphene-based biosensors for detection of bacteria and their metabolic activities. J Mater Chem 21:12358–12362

    Article  CAS  Google Scholar 

  23. Chang J, Jin M, Yao F, Kim TH, Le VT, Yue H, Gunes F, Li B, Ghosh BA, Xie S, Lee YH (2013) Asymmetric supercapacitors based on graphene/MnO2 nanospheres and graphene/MoO3 nanosheets with high energy density. Adv Funct Mater 23:5074–5083

    Article  CAS  Google Scholar 

  24. Liu Y, Dong X, Chen P (2012) Biological and chemical sensors based on graphene materials. Chem Soc Rev 41:2283–2307

    Article  CAS  Google Scholar 

  25. Khan M, Tahir MN, Adil SF, Khan HU, Siddiqui MRH, Al-warthan AA, Tremel W (2015) Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications. J Mater Chem A 3:18753–18808

    Article  CAS  Google Scholar 

  26. Huang Y, Liang JJ, Chen Y (2012) An overview of the applications of graphene-based materials in supercapacitors. Small 8:1805–1834

    Article  CAS  Google Scholar 

  27. Yu M, Ma YX, Liu JH, Li SM (2015) Polyaniline nanocone arrays synthesized on three-dimensional graphene network by electrodeposition for supercapacitor electrodes. Carbon 87:98–105

    Article  CAS  Google Scholar 

  28. Cao X, Yin Z, Zhang H (2014) There-dimensional graphene materials: preparation, structures and appliction in supercapacitors. Energy Environ Sci 7:1850–1865

    Article  CAS  Google Scholar 

  29. Sha JW, Gao CT, Lee SK, Li YL, Zhao NQ, Tour JM (2016) Preparation of three-dimentional graphene foams using powder metallurgy templates. ACS Nano 10:1411–1416

    Article  CAS  Google Scholar 

  30. He XJ, Zhang HB, Zhang H, Li XJ, Xiao N, Qiu SJ (2014) Direct synthesis of 3D hollow porous graphene balls from coal tar pitch for high performance supercapacitors. J Mater Chem A 2:19633–19640

    Article  CAS  Google Scholar 

  31. Li B, Yao F, Bae JJ, Zamfir MR, Le DT, Pham DT, Yue HY, Lee YH (2015) Hollow carbon nanospheres/silicon/alumina core-shell film as an anode for lithium-ion batteries. Sci Rep 5:7659

    Article  CAS  Google Scholar 

  32. Yi SY, Lee JH, Hong HG (2013) A selective determination of levodopa in the presence of ascorbic acid and uric acid using a glassy carbon electrode modified with reduced graphene oxide. J Appl Electrochem 44:589–597

    Article  Google Scholar 

  33. Ghodsi J, Rafati AA, Shoja Y (2016) First report on hemoglobin electrostatic immobilization on WO3 nanoparticles: application in the simultaneous determination of levodopa, uric acid, and folic acid. Anal Bioanal Chem 408:3899–3909

    Article  CAS  Google Scholar 

  34. Atta NF, El-Kady MF, Galal A (2010) Simultaneous determination of catecholamines, uric acid and ascorbic acid at physiological levels using poly(N-methylpyrrole)/Pd-nanoclusters sensor. Anal Biochem 400:78–88

    Article  CAS  Google Scholar 

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Acknowledgements

This work is supported by the Natural Science Foundation of Heilongjiang Province (LC2015020), Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (2015192), the Innovative Talent Fund of Harbin city (2016RAQXJ185) and Science Funds for the Young Innovative Talents of HUST (201604).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Xin Gao, Hongyan Yue, Shanshan Song, Shuo Huang, Xuanyu Lin, Erjun Guo, Bao Wang, Enhao Guan, Hongjie Zhang & Pengfei Wu

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

  3. Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea

    Bing Li

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  1. Xin Gao
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  2. Hongyan Yue
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  3. Shanshan Song
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  4. Shuo Huang
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Correspondence to Hongyan Yue.

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Gao, X., Yue, H., Song, S. et al. 3-Dimensional hollow graphene balls for voltammetric sensing of levodopa in the presence of uric acid. Microchim Acta 185, 91 (2018). https://doi.org/10.1007/s00604-017-2644-y

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