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Electrochemical method for determination of levodopa in the presence of uric acid using In2S3 nanospheres on 3D graphene-modified ITO glass electrode

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Abstract

An electrochemical sensor that can sensitively detect levodopa without fragile and expensive antibodies has been prepared on the basis of indium sulfide and graphene. The indium sulfide nanospheres synthesized by a hydrothermal method were grown on the surface of three-dimensional graphene prepared by chemical vapor deposition. The graphene maintains a good 3D structure and the indium sulfide nanospheres increases the specific surface area of graphene. The composite possesses a low detection limit of 87 nM (S/N = 3) and the sensitivity of it reaches 1.98 μA μM−1 cm−1. Also, good electrochemical performance, selectivity, and stability make it available to be used for detecting real biomolecules.

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Acknowledgements

This work is supported by the fundamental research foundation for University of Heilongjiang province (LGYC2018JQ012) and the foundation for selected overseas Chinese Scholar, Ministry of personnel of Heilongjiang province (2018383).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Xinrui Guo, Hongyan Yue, Xin Gao, Hongtao Chen, Pengfei Wu, Teng Zhang & Zengze Wang

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

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  1. Xinrui Guo
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  2. Hongyan Yue
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  3. Shuo Huang
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  4. Xin Gao
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  5. Hongtao Chen
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Correspondence to Hongyan Yue.

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Guo, X., Yue, H., Huang, S. et al. Electrochemical method for determination of levodopa in the presence of uric acid using In2S3 nanospheres on 3D graphene-modified ITO glass electrode. J Mater Sci: Mater Electron 31, 13680–13687 (2020). https://doi.org/10.1007/s10854-020-03925-3

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