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Synthesis of graphene/ZnO nanoflowers and electrochemical determination of levodopa in the presence of uric acid

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Abstract

ZnO nanoflowers (ZnONFs) were synthesized by a simple hydrothermal method. Then, ZnONFs suspension was sprayed onto the indium tin oxide coated glass. Finally, graphene was deposited on the surface of ZnONFs (graphene/ZnONFs) by chemical vapor deposition, which is used to electrochemically determine levodopa in the presence of uric acid. The results show that the length and diameter of ZnONFs are ∼ 2.5 µm and 50 nm, respectively. Graphene with multi-layers and some defects are deposited on the surface of ZnONFs. The sensitivity and measured limit of detection of the graphene/ZnONFs for levodopa are 0.32 µA µM−1 and 1 µM in the range of 1–60 µM, respectively. The graphene/ZnONFs also show good selectivity, repeatability and stability for the determination of levodopa. The proposed electrode is also successfully used to determine levodopa in human urine samples and it is potential for use in clinical research.

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Acknowledgements

This work is supported by the Natural Science Foundation of Heilongjiang Province (LC2015020), Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (2015192), the innovative talent fund of Harbin city (2016RAQXJ185) and Science Funds for the Young Innovative Talents of HUST (201604).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Hong Yan Yue, Bao Wang, Shuo Huang, Xin Gao, Shan Shan Song, En Hao Guan, Hong Jie Zhang, Peng Fei Wu & Xin Rui Guo

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

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  1. Hong Yan Yue
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  2. Bao Wang
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Correspondence to Hong Yan Yue.

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Yue, H.Y., Wang, B., Huang, S. et al. Synthesis of graphene/ZnO nanoflowers and electrochemical determination of levodopa in the presence of uric acid. J Mater Sci: Mater Electron 29, 14918–14926 (2018). https://doi.org/10.1007/s10854-018-9630-y

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  • DOI: https://doi.org/10.1007/s10854-018-9630-y

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